摘要
目的：观察杞棋饮乙醇提取物（EEQY）对小鼠酒精性肝损伤的保护作用。方法：昆明种小鼠随机分为EEZY75、150、300mg／kg组，益肝灵70mg／ks组和模型组。给药的同时。灌胃56度白酒12mL／ks，连续30天。以血清中谷氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）和丙二醛（MDA）、谷胱甘肽（GSH）和超氧化物歧化酶（SOD）的水平作为指标。观察EEZY物对酒精性肝损伤的保护作用。结果：EEZY150、300mg／ks组小鼠血清ALT、AST和MDA水平明显低于模型组（P〈0．05～0．01）；GSH和SOD的水平明显高于模型组（P〈0．05～0．01）。结论：EEZY对酒精性肝功能损伤有显著的保护作用。
Objective：To study the protective effects of ethanol extract of Qiju Yin （EEQY） on liver damage induced by alcohol in mice. Method： The mice were randomly divided into 5 groups, which were model control group, EEQY （ 75, 150,300mg/kg） group and Yiganling （70mg/kg）group. 12ml/kg of 56% （v/v） ethanol was ig given to all mice for 30 days together with drugs. The content of ALT, AST, MDA and the activity of glutathione peroxidase （ GSH - Px） and SOD in the serum were measured to evaluate the protective effects of EEQY. Results ： EEQY significantly decreased the content of ALT, AST,MDA and elevated the activity of GSH- Px and SOD in serum. Concision： EEQY shows protective effects on liver damage induced by alcohol in mice.
出处
《辽宁中医杂志》
CAS
北大核心
2006年第7期898-899,共2页
Liaoning Journal of Traditional Chinese Medicine
关键词
杞棋饮
醇提取物
酒精
肝损伤
Qiju Yin
ethanol extract
ethanol
liver damage
作者简介
宋成军（1972-），男，河北承德人，讲师，学士，主要从事解剖学研究。
