摘要
目的观察氟比洛芬酯超前镇痛对经腹胆囊切除术后疼痛的影响。方法80例腹式胆囊切除患者随机分为A、B两组,每组各为40例,均采取气管内全麻。A组为实验组,在术前30 m in静注1 mg.kg-1的氟比洛芬酯(用生理盐水稀释至15 m l);B组为对照组,在手术前30 m in静注生理盐水15 m l。术后用视觉模拟评分法(VAS)双盲评估患者术后12、24、48、72 h的疼痛感觉程度,并观察与氟比洛芬酯有关的不良反应。结果A组病人术后24 hVAS评分明显低于B组(P<0.05),两组的不良反应发生率差异无显著意义。结论氟比洛芬酯超前镇痛能有效减轻患者术后疼痛,不良反应少,但应进一步探讨氟比洛芬酯多模式用药以降低围术期总的疼痛体验。
Aim To assess the effects of preemptive analgesia with flurbiprofen on the postoperative pain for patients who are undergoing abdominal cholecystectomy. Methods 80 cases scheduled for selective surgery of abdominal choleystectomy were randomly divided into A and B groups. 30 minutes before operation, the patients in group A received flurbiprofen 1 mg· kg^-1 and group B received normal saline 15 ml. The effects of analgesia after operation were assessed by visual analogue scale （VAS） at 12, 24, 48, 72 hours after opera- tion, and side effects were also assessed. Results The VAS of group A was lower than that of group B during 24 hours after operation （P 〈0.05） ,and the side effects such as vomit and nausea were same between group A and B（P 〉0.05）. Conclusion Preemptive analgesia with flurbiprofen 1 mg · kg^-1 could provide satisfactory painful relief with no obvious side effects during 24 hours after abdominal cholecystectomy, but we should continue to investigate more useful models of flurbiprofen in order to fully relieve postoperative pain.
出处
《安徽医药》
CAS
2006年第8期571-572,共2页
Anhui Medical and Pharmaceutical Journal
关键词
氟比洛芬酯
超前镇痛
flurbiprofen
preemptive analgesia
