摘要
目的:探讨幽门螺旋杆菌细胞毒素(HP-CagA)与急性脑梗死的相关性。方法:100例新发脑梗死患者(脑梗死组)及50例健康对照者(对照组)均行HP-CagA-IgG抗体、中性粒细胞、C-反应蛋白(CRP)、血脂、血纤维蛋白原(Fbg)测定及经颅多普勒检查。结果:脑梗死组血清HP-CagA-IgG抗体阳性率(65%)高于对照组(38%),HP-CagA-IgG抗体阳性的脑梗死患者颈动脉粥样斑块、颈动脉狭窄阳性率及血CRP、血Fbg水平均高于HP-CagA-IgG抗体阴性的脑梗死患者。结论:HP-CagA感染与急性脑梗死的发生有关,可能为脑梗死的又一危险因素。
Objective： To investigate the correlation between cytotoxin-associated gene-A-bearing strains of helicobacter pylori （HP-CagA） and acute cerebral infarction. Methods： 100 patients with new cerebral infarction and 50 healthy individuals （control） were enrolled in this trial.IgG antibody of HP-CagA, neutrophilic granulocyte, C-reactive protein, lipids and fibrinogen of blood were estimated by intracranial Doppler. Results： The positive rate of HP-CagA antibody of patients with cerebral infarction was 65% which was significantly higher than that of the control （ 38 %）, The positive rate of carotid stenosis, atheromatous plaque of carotid artery, C-reactive protein and fibrinogen of blood plasma in cerebral infarction patients with positive HP-CagA-IgG antibody were significantly higher than that in the negative. Conclusion： There is an association between HP-CagA infection and acute cerebral infarction, HP-CagA infection probably become another dangerous factor for acute cerebral infarction.
出处
《天津医药》
CAS
北大核心
2006年第7期466-467,共2页
Tianjin Medical Journal
关键词
螺杆菌
幽门
螺杆菌
感染
脑梗死
helicobacter pylori hehcobacter infections brain infarction
