摘要
AIM： To study the effect of a one-year lamivudine regimen in patients with chronic hepatitis B. METHODS： Medical records of HBeAg negative hepatitis B patients who attended a hepatitis clinic in Tehran between March 2002-March 2004 were evaluated. The patients received 100 mg lamivudine tablets once daily for at least 12 mo. Liver enzymes and complete blood count were checked at baseline and the end of treatment （12th mo） and 6 mo after discontinuation of treatment. RESULTS： Of all patients, 24 were excluded. Of 71 patients left, 58 （81.7%） were men. Mean age of the patients was 38 ± 14 years. Mean level of ALT in serum was 1437 ± 205 nkat/L at baseline with a significant reduction at the end of treatment to a mean level of 723 ± 92 nkat/L （P = 0.002）. In 38 patients （53.5%）, the ALT level was normal after one-year treatment. Five patients （7.3%） relapsed （biochemically） within 6 mo after discontinuing lamivudine therapy （the patients with good end of treatment response）. Mean level of AST in serum was 1060 ± 105 nkat/L at baseline which decreased significantly to 652 ± 75 nkat/L at the end of treatment （P = 0.002）. CONCLUSION： Over half （53.5%） of chronic hepatitis B patients with HBeAg negative have normal liver enzyme level at 12-mo lamivudine therapy.
瞄准：与长期的肝炎 B 在病人学习一个年 lamivudine 政体的效果。方法：在在 3 月 2002-March 日 2004 之间的德黑兰出席了一个肝炎诊所的 HBeAg 否定肝炎 B 病人的医药记录被评估。病人收到了为至少 12 瞬间从前每日的 100 片 mg lamivudine 药片。肝酶和全部血细胞计数在治疗的中止以后在基线和治疗(第 12 瞬间) 和 6 瞬间的结束被检查。结果：所有病人， 24 被排除。离开的 71 个病人，(81.7%) 58 是人。病人的吝啬的年龄是 38 +/- 14 年。在浆液的中高音的吝啬的水平是在有在到一个平均数的治疗的目的重要减小的基线的 205 nkat/L 723 +/- 铺平的 1437 +/- 92 nkat/L (P = 0.002 ) 。在 38 个病人(53.5%) ， ALT 水平在一个年治疗以后是正常的。五病人(7.3%) relapsed (简历化学上) 在在中止 lamivudine 治疗(有治疗反应的好结束的病人) 以后的 6 瞬间以内。在浆液的著名计算机生产厂商的吝啬的水平是 1060 +/- 在显著地减少了到 652 +/- 的基线的 105 nkat/L 在治疗的目的 75 nkat/L (P = 0.002 ) 。结论：在长期的肝炎 B 的一半(53.5%) 上，有 HBeAg negative 的病人在 12 瞬间 lamivudine 治疗有正常的肝酶水平。
作者简介
Correspondence to： Amir Houshang Mohammad Alizadeh, Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, 7th floor, Taleghani Hospital, Yaman Str., Evin, Tehran 19857, Iran. article@rcgld.org Telephone： ＋98-21-2418871 Fax： ＋98-21-2402639
