摘要
目的探讨WHO(2000)Ⅰ级脑膜瘤“脑膜尾征”(MRI)形成的组织病理基础及临床意义。方法切除46例脑膜瘤及其周围硬膜,对比脑膜瘤周围硬膜MRI特点进行病理学和免疫组织化学(VEGF)观察。结果46例硬脑膜标本组中有肿瘤浸润者32例,14例无肿瘤侵袭。在35例MRI(增强)显示存在“脑膜尾征”(MRI)的标本中有15例肿瘤侵入硬脑膜血管内。距肿瘤边缘1．0 cm范围内硬膜标本肿瘤存在几率为100．00%,1．5cm、2．0cm处分别为35．00%和25．00%。VEGF在脑膜瘤中表达程度与其侵袭性行为之间具有统计学意义(P＜0．05)。脑膜瘤向其毗邻硬脑膜组织浸润最明显部位VEGF表达最强。结论“脑膜尾征”形成机制是由肿瘤细胞侵入硬脑膜血管所引起的。脑膜瘤对周围至少2．0cm范围内的硬脑膜存在浸润的可能性。VEGF在脑膜瘤侵袭行为中有着重要作用。
Objective To study the histopathological mechanism and clinical significance of dural tail sign （MRI） within meningiomas of WHO Ⅰ （2000）. Methods 46 cases with meningioma were removed as well as the adjacent dura mater. Comparative pathological and immunohistochemical （VEGF） study was carried out at the point of attachment of the tumor and the adjacent dura mater on MRI. Results There were 46 cases of dural preparation, out of which 32 were invaded by tumor and 14 were not. 15 cases showed tumor cells invading into the dural mater and vessels within 35 cases with dural tail sign. The levels of VEGF expression in meningiomas were positive related with their invasive behaviors （ P 〈 0.05 ）. The strongest expression of VEGF is located at the spots invaded by tumor cells in adjacent dura mater. Conclusions The mechanism of dural tail sign is suggested that tumor cells invade dural vessels. VEGF plays an important role on the invasive behaviors of meningiomas.
出处
《中华神经外科杂志》
CSCD
北大核心
2006年第7期420-423,共4页
Chinese Journal of Neurosurgery
作者简介
周岩原为空军航空医学研究所附属医院神经外科，现为在读博士
通讯作者
