摘要
目的研究川明参镇咳祛痰有效部位。方法采用浓氨水喷雾法,观察川明参3个提取部位对浓氨水诱发小鼠咳嗽潜伏期和咳嗽次数的影响。采用小鼠气管段酚红法研究川明参3个提取部位的祛痰作用。结果川明参95%乙醇提取物、水提物和正丁醇提取物均可显著地延长浓氨水诱发小鼠咳嗽的潜伏期,并且减少咳嗽次数(P<0.01)。川明参水提物可明显增加小鼠气管酚红排泌量(P<0.01),而95%乙醇提取物和正丁醇提取物与空白组相比较没有明显差异。结论川明参95%乙醇提取物、水提取物、正丁醇提取物有明显镇咳作用;川明参水提物具有祛痰作用。
Objective To investigate the antitussive and expectorant fractions of Chuanmingshen violaceum. Methods ①Method of nebulization with strong ammonia was conducted to observe the effects of three fractions of Chuanmingshen violaceum on the incubation period of cough and the coughing frequency in mice induced by strong ammonia. ②Tracheal phenol red test in mice was conducted to investigate the expectorant effects of these three fractions. Results ①The 95% alcohol, water and n - butanol extracts of Chuanmingshen violaceum slgnificanfly prolonged the incubation period of cough and reduced the coughing frequency in mice （P 〈0.01 ）.②The water extract obviously increased the tracheal excretion of phenol red（ P 〈0.01 ）, while the 95% alcohol and n - butanol extracts showed no significant differences compared with that of the control group. Conclusion The 95% alcohol,water and n - butanol extracts of Chuanmingshen violaceum have antitussive effects. The water extract has an expectorant effect as well.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2006年第7期1121-1122,共2页
Lishizhen Medicine and Materia Medica Research
基金
四川省中医药管理局科研基金资助项目(No.2004A16)
关键词
川明参
镇咳
祛痰
Chuanmingshen violaceum
Antitussive
Expectorant
作者简介
张梅（1963-），女（汉族），四川成都人，现任成都中医药大学副教授，博士学位，主要从事中药及其复方物质基础及质量标准化研究工作．
