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双膦酸盐治疗恶性肿瘤骨转移的基础研究与临床实践 被引量:8

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摘要 转移性骨病是晚期肿瘤常见而又严重的并发症,肿瘤转移到骨时,骨吸收和新骨形成之间的动态平衡被破坏,引起肿瘤生长和骨破坏,导致骨痛、病理性骨折、高钙血症、以及神经表现(脊髓压迫)等骨相关事件(SREs)发生;双膦酸盐的治疗在于降低SREs发生的风险,以缓解骨痛、恢复正常功能、改善生活质量为目的,是其他治疗转移性骨病的主要措施之一;常用的和新一代双膦酸盐在治疗多发性骨髓瘤、乳腺癌、前列腺癌、肺癌、肾细胞癌以及其他实体瘤所致的转移性骨病已被证明是有效、安全和可耐受的,并广泛用于临床。
作者 董梅 冯奉仪
出处 《癌症进展》 2006年第4期366-369,共4页 Oncology Progress
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  • 1[1]Clines GA and Guise TA.Hypercalcaemia of malignancy andbasic research on mechanisms responsiblefor osteolytic and osteoblastic metastasisto bone.Endocrine Related Cancer,2005,12:549
  • 2[2]Bukowski JF,Dascher CC,Das H.Alternative bisphosphonate targets and mechanisms of action.Biochem Biophys Res Commun,2005,328 (3):746
  • 3[3]Ferretti G,Fabi A,Carlini P,et al.Zoledronic-acid-induced circulating level modifications of angiogenic factors,metalloproteinases and proinflammatory cytokines in metastatic breast cancer patients.Oncology,2005,69 (1):35
  • 4[4]Clezardin P,Ebetino FH,Fournier PG.Bisphosphonates and cancer-induced bone disease:Beyond their antiresorptive activity.Cancer Res,2005,65 (12):4971
  • 5[5]Pavlakis N,Schmidt R,Stockler M.Bisphosphonates for breast cancer.Cochrane Database Syst Rev,2005,20; (3):CD003474
  • 6[6]Hillner BE,Ingle JN,Chlebowski RT,et al.American Society of Clinical Oncology 2003 update on the role of bisphosphonates and bone health issues in women with breast cancer.J Clin Oncol,2003,21:4042
  • 7[7]Peter R,Mishra D,Fraser WD.Severe hypocalcaemia after being given intravenous bisphophonate.BMJ,2004,328(7435):335
  • 8[8]Fraunfelder FW,Fraunfelder FT.Bisphosphonates and ocular inflammation.N Engl J Med,2003,348 (12):1187
  • 9[9]Ruggiero SL,Mehrotra B,Rosenberg TJ,et al.Osteonecrosis of the jaws associated with the use of bisphosphonates:A review of 63 cases.J Oral Maxillfac Sug,2004,62 (5):527
  • 10[10]Purcell PM,Boyd IW.Bisphosphonates and osteonecrosis of the jaw.Med J Aust,2005,182 (8):417

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