摘要
目的探讨2型糖尿病患者心脑血管并发症与血糖、血压、血脂、胰岛素抵抗的关系。方法将286例2型糖尿病患者按有无合并心脑血管并发症进行分组,观察空腹血糖(FBG)、餐后血糖(PBG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、餐后胰岛素(PINS)、空腹C肽、餐后C肽及血脂水平,并计算胰岛素抵抗指数(IR)、胰岛素敏感指数(ISI),分析这些参数与心脑血管并发症的关系。结果2型糖尿病合并心脑血管并发症组患者年龄较大、血压较高,体质指数(BMI)、FINS、PINS、空腹及餐后C肽、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白E(ApoE)、IR均显著升高,ISI显著下降,与2型糖尿病无心脑血管并发症组相比,差异有显著性。而FBG、PBG、HbA1c、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)差异则无显著性。结论胰岛素抵抗、血脂异常、血压升高是2型糖尿病合并心脑血管并发症的危险因素,参与心脑血管并发症的发生发展。
Objective To study the relationship between cerebreeardiovascular complications and blood glucose as well as insulin resistance, serum lipid, and blood pressure in patients with type 2 diabetes mellitus. Methods 286 type 2 diabetes patients were divided into two groups according to cerebrovascular complications. The levels of fasting blood glucose （ FBG ）, postprandial blood glucose （ PBG）, glycosylated hemoglobin A1c （ HbA1c）, fasting insulin （FINS）, postprandial insulin （PINS）, fasting peptide C and postprandial peptide C and serum lipid were determined in both groups. The insulin resistance index （IR） and insulin sensitivity index （ISI） were calculated. Results Older - age and higher blood pressure （BP） , as well as increased levels of BMI, FINS, PINS, LDL-C, ApoE, IR and poptide C were found in the diabetes patients with cerebrovascular complications, significantly different from those of the patients without complications. There were no significant differences between groups in levels of FBG, PBG, HbA1c, TCH, TG, HDL - C, APOA and APOB. Conclusion IR, abnormality of lipid and the increase of blood pressure are the risk factors for cerebrovascular complications in type -2 diabetes, which play the important roles in the development of cerebrovascular complications.
出处
《中国综合临床》
北大核心
2006年第8期689-691,共3页
Clinical Medicine of China
关键词
2型糖尿病
胰岛素抵抗
血脂异常
Type 2 diabetes
Insulin resistance
Abnormality of lipid
