摘要
为探讨严重烧伤休克期切痂与肠源性细菌感染的关系,作者采用SPF大鼠150只,随机分成三组:休克期切痂组(B组)与常规切痂组(C组)均致30%TBSAⅢ度烫伤,伤后1小时开始补液治疗,分别于伤后24小时、5天切痂植皮。另设单纯植皮组(A组),不烫伤,仅植皮对照。结果显示,B组切痂前、后血浆LPS及TNF含量均明显低于C组,但高于A组(P<0.05~0.001),痂下菌量(1.5×103±0.3×10cfu/g组织)也明显低于C组(4.3×106±1.7×10cfu/g组织)(P<0.001)。B组内脏细菌检出率显著低于C组(P<0.05~0.01)。结果表明,休克期切痂可以减轻肠源性内毒素血症,及其细菌和毒素移位。内毒素在肠道内细菌和毒素移位中起重要作用。
SPFrats(Wistar)wererandomlydividedinto3groups(1)simpleskingraftinggroup(GroupA).(2)Escharectomyduringburnshockgroup(GroupB).(3)Routineescharectomygroup(GroupC)Ful-thicknessburnof30%TBSAwasproducedinGroupBandGroupC.Onehourafterscaldintravenousfluidreplacementwasinstituted.Firststageescharectomyhasbeenperformed24hoursafterburnand5dayspostburn.TherusultsdemonstratedthatthecontentsofbothplasmaLPSandTNFinGroupBweresignificantlylowerascomparedwiththeseinGroupC.Ourdataindicatedes-charectomyduringburnshockwouldefectivelyelimanatetheefectsoftheendotoxemia.Endotoxinplayanimportantroleinthebacterialandendotoxictranslocation.
出处
《中华外科杂志》
CAS
CSCD
北大核心
1996年第7期443-446,共4页
Chinese Journal of Surgery