摘要
目的探讨慢性日本血吸虫病疾病的询检指标并评价其效度。方法选择湖南省汉寿县随机抽取51个村,以5岁以上常住人口为调查对象。用血吸虫抗体血清学(ELISA)进行筛查,对ELISA阳性者做腹部B超和询检,同时在不同流行强度村选取等比例的ELISA阴性者做对照。用非条件logistic回归方法分析询检指标与血清学、B超检查结果的关系;用贝叶斯(Bayes)判别分析检验询检与血清学、血吸虫病肝纤维化的符合程度。结果血清学检查26426人,阳性率为5.2%(1380/26426)。对ELISA阳性者1264例和阴性者1446例分别进行询检和B超检查。Bayes判别分析结果显示:过去2周内腹泻、黏血便、乏力、疫水接触史、治疗总次数等询检指标的判别结果与ELISA、B超结果的交叉验证符合率分别为75.9%和75.4%。结论问卷询检的效度良好,对筛检慢性日本血吸虫病患者有重要价值。
Objective To study the indicators and validity of inquiry in the screening of chronic schistosomiasis japonica. Methods 51 villages of Hanshou county were selected at random in Hunan Province and the whole resident （〉6 months/year） population aged 5 years and above was eligible for inclusion in the study o Inquiry through questionnairing, serological test （ELISA） and B type uhrasonography were applied respectively to screen chronic cases and evaluate morbidity due to schistosome infection. Logistic analysis was performed to explore the relationship between indicators of questionnaire and the results of ELISA and abdominal ultrasonography. Bayes discriminant analysis was used to assess consistency of inquiry and ELISA, inquiry and the degree of hepatic fibrosis. Results 26 426 inhabitants in the endemic villages were screened by ELISA with 1 380 （5.2%） positive. 1 264 sero-positive and 1 446 seronegative cases were asked questions relating to schistosomiasis and examined by abdominal ultrasonography. Inquiry indices such as self-reported diarrhea, stool with mucus and fatigue during the last two weeks, history of infested water contact and times of treatment were specific to chronic schistosomiasis. The coincident rate for validation was 75.9% between inquiry and ELISA, and 75.4% between inquiry and hepatic fibrosis degree. Conclusion Validity of inquiry was satisfactory in screening chronic schistosomiasis in endemic areas.
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
2006年第3期230-235,共6页
Chinese Journal of Parasitology and Parasitic Diseases
基金
国家自然科学基金(No.30590373)
联合国开发计划署/世界银行/世界卫生组织热带病研究与培训特别规划资助项目(TDRA30298)~~
关键词
询检
效度
慢性日本血吸虫病
ELISA
B型超声
Inquiry
Questionnaire
Validity
Chronic schistosomiasis japonica
ELISA
Ultrasonography
作者简介
通讯作者．E-mail：ipdzhouxn@sh163．net
