期刊文献+

40例髓母细胞瘤综合治疗分析 被引量:3

Retrospective study of synthesis therapy on 40 cases of medullblastoma
在线阅读 下载PDF
导出
摘要 目的探讨髓母细胞瘤的综合治疗及预后影响因素。方法40例经手术切除及病理确诊的不同年龄患者,单纯手术治疗组12例,手术+全脑全脊髓放疗组18例,手术+全脑全脊髓放疗+化学治疗组10例。结果术后全脑全脊髓放疗组生存率显著高于单纯手术组,联合化疗组较对照组未体现出优越性,术后1个月内行放疗者生存率高于对照组,年龄是影响预后的因素。结论确诊为髓母细胞瘤者应在手术切除术后两周左右常规行全脑全脊髓放疗。 [ Objective] To discuss the integrate therapy and the influential factors for pragno sis of Medulloblastoma. [Method] 40 patients in different age with Medullblastoma demonstrated by pathology, 25 patients were treated by the whole brain and spinal cord radiotherapy, among them, chemotherapy had been done in 10 patients. Other 3 patients, only treated by the whole brain radiotherapy within one month after operation. [Result] Patients who were treated by the whole brain and spinal cord radiotherapy after operation had a higher survive ratio than those only treated by operation. But chemotherapy was not good. The patients whose radiotherapy had been started within one month after operation had a higher survive ratio than those beyong one month. Age was not the influential factor of pragnosis. [Conclusion] Patient with Medullblastoma should generally have a whole brain and spinal cord radiotherapy in about 2 weeks after operation.
出处 《中国医学工程》 2006年第3期283-285,共3页 China Medical Engineering
关键词 髓母细胞瘤 手术 放射疗法 化学疗法 medullblastoma operation radiotherapy chemotherapy
作者简介 [通讯作者]涂青松,联系电话:0731-4327471。
  • 相关文献

参考文献3

  • 1舒凯,雷霆,李龄.髓母细胞瘤诊断与治疗研究[J].中华神经外科疾病研究杂志,2005,4(4):382-384. 被引量:12
  • 2Joann L. Ater,Jan van Eys,Shiao Y. Woo,Bartlett Moore III,Donna R. Copeland,Janet Bruner. MOPP chemotherapy without irradiation as primary postsurgical therapy for brain tumors in infants and young children[J] 1997,Journal of Neuro - Oncology(3):243~252
  • 3M. P. Aragonés,R. Magallón,C. Piqueras,L. Ley,J. Vaquero,G. Bravo. Medulloblastoma in adulthood: Prognostic factors influencing survival and recurrence[J] 1994,Acta Neurochirurgica(1-2):65~68

二级参考文献15

  • 1McNeil DE, Cote TR, Clegg L, et al. Incidence and trends in pediatric malignancies Medulloblastoma/primitive Neuroectodermal tumor: a SEER update [J]. Med Pediatr Oncol, 2002, 39(3): 190-194.
  • 2Paraf F, Jothy S, Van Meir EG. Brain tumor-polyposis syndrome: two genetic disease? [J]. J Clin Oncol, 1997, 15(7): 2744-2758.
  • 3Khalili K, Krynska B, Del Valle L, et al. Medulloblastomas and the human neurotropic polyomavirus JC virus [J]. Lancet, 1999, 353(9195): 1152-1153.
  • 4Giangaspero F, Bigner SH, Kleihues P, et al. Medulloblastoma [A]. In: Kleihues P, Cavanee WK (eds). World Health Organization classification of tumours: Tumours of the nervous system[M]. Lyon: IARC Press, 2000: 129-137.
  • 5Leonard JR, Cai DX, Rivet DJ, et al. Large cell/anaplastic medulloblastomas and medullomyoblastomas: clinicopathological and genetic features [J]. J Neurosurg, 2001, 95(1): 82-88.
  • 6Michiels EM, Weiss MM, Hoovers JM, et al. Genetic alterations in childhood medulloblastoma analyzed by comparative genomic hybridization [J]. J Pediatr Hematol Oncol, 2002, 24(3): 205-210.
  • 7Grotzer MA, Janss AJ, Fung K, et al. TrkC expression predicts good clinical outcome in primitive neuroectodermal brain tumors [J]. J Clin Oncol, 2000, 18(5): 1027-1035.
  • 8Bellezza G, Pietropaoli N, Sidoni A. Medulloblastoma during pregnancy. Description of a case with extraneural metastases and review of the literature [J]. Pathologica, 1997, 89(3): 301-303.
  • 9Halperin EC, Constine LS, Tarbell NJ, et al. Tumors of the posterior fossa and the spinal cana. Pediatric radiation oncology [M]. 3rd edition. Philadelphia: Lippincott, William&Wilkins, 1999: 80-125.
  • 10Zeltzer PM, Boyett JM, Finlay JL, et al. Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study [J]. J Clin Oncol, 1999, 17(3): 832-845.

共引文献11

同被引文献25

  • 1李龄,周游,李志峰.儿童髓母细胞瘤的治疗[J].中华神经外科杂志,1995,11(5):293-295. 被引量:15
  • 2钱普东,许康雄.36例松果体区生殖细胞瘤的治疗[J].河南肿瘤学杂志,2005,18(6):406-408. 被引量:5
  • 3Packer RJ,Cogen P,Vezina G,et al.Medulloblastoma:clinical and biologic aspects[J].Neurooncology,1999,1:232-250.
  • 4Sagers MP.Radiotherapy of medulloblastoma[J].Neurological urger,1973,3:1480-1484.
  • 5Abasioglu U,Uzel O,Sengoz M,et al.Medulloblastoma in adults:treatment results and prognostic factors[J].Radiat Oncol Biol Phys,2002,54:855-860.
  • 6Del Charco JO,Bolek TW,Mccolloug WM,et al.Medulloblastoma:time-dose relationship based on a 30 year review[J].Radiat Oncol BiolPhys,1998,42:147-154.
  • 7Thomas PR,Deutsch M,Kepner JL,et al.Low-stage medulloblastoma:final analysis of trial comparing standard-dose with reduced-dose neuraxis irradiation[J].J Clin Oncol,2000,18(16):3004-3011.
  • 8Spreafico F, Massimino M, Gandola L, et al. Survival of adults treated for medulloblastoma using pediatric protocols[J]. Eur J Cancer, 2005,41 (2) 1304-1310.
  • 9Arnold CP. Long-term survival in a child with extraneural metas- tasis from medulloblastoma treated with chemo-radiotherapy[J]. Med Pediatr Oncol, 2003,40(6) : 396-397.
  • 10Kim W,Choy W,Dye ],et al. The tumor biology and molecular characteristics of medulloblastoma identifying prognostic factors associated with survival outcomes and prognosis~J~. J Clinical Neurosci, 2011,18(7) : 886-890.

引证文献3

二级引证文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部