摘要
目的探讨静脉留置针封管频次与静脉炎的关系。方法取种系相同、体重相近的新西兰健康大耳白兔21只,以兔双耳外侧的耳缘静脉作为实验血管,随机分成第1组(n=22)和第2组(n=20),采用静脉留置针输液,以10gtt/min的速度输入0·9%氯化钠注射液30ml,1次/d。第1组液体输注完毕用肝素盐水封管1次,与下次输液间隔时间为23h15min;第2组在第1次封管后12h再封管1次,第2次封管与次日输液间隔时间为11h15min。两组均保留72h,第1组封管3次、第2组封管6次后拔除静脉留置针。以穿刺点为起点取长2cm、宽1cm含静脉血管和耳廓组织的活体标本做病理切片,观察静脉血管的病理变化。结果两组血管壁未发现炎性细胞浸润,炎性细胞均分布在血管周围组织;两组血管周围组织炎症发生情况比较,差异有显著性意义(均P<0·01);两组血管内血栓形成情况基本相同(均P>0·05)。结论相同留置时间,增加静脉留置针封管次数可加重静脉周围组织炎症的程度。
Objective To study the relationship between the flushing times of IV catheter and phlebitis. Methods Twenty- one healthy New Zealand rabbits with the same race and weight were randomly divided into two groups. The veins at the outside edges of the two ears of rabbits were taken as tested blood tubes for the infusion with IV catheter. 30 ml 0.9% sodium chloride injection was infused once daily at the speed of 10 drop/min. The tubes in first group （n=22） were sealed with heparinized saline with intervals of 23 h and a quarter between the flushing times after intravenous infusion. In second group （n=20）, the tubes were sealed once again after the first time in 12 h and the intervals between the second sealing and infusion on the next day was 11 h and a quarter. The first group was sealed 3 times and the second 6 times. Both retained for 72 h and then the indwelling intravenous catheter was withdrawn. Two cm long and 1 cm width samples with vein and ear structure were taken as pathological section for the observation of pathologic change of the vein. Results No inflammatory cell infiltrates were found on the vascular walls in both groups. The in- flammatory cells were distributed the tissues around the vessels with the difference being significant between the two groups （all P〈0. 01）. There was no significant difference in the intravascular thrombosis between the two groups （all P〈0.05）. Conclusion In the same indwelling time, the increased flushing times of Ⅳ catheter could aggravate the tissue inflammation around the veins.
基金
河北省科技厅科技攻关项目(052761253)
关键词
静脉留置针
封管
静脉炎
venous indwelling needle
flushing
phlebitis
