摘要
从海洋来源的放线菌Streptomycessp.3275中分到7个化合物,经IR,ESIMS,NMR等光谱数据鉴定及与文献对照,确定其结构为环(脯缬)(1),环(脯酪)(2),环(脯甘)(3),环(脯异亮)(4),环(脯亮)(5),胆甾醇(6)及1甲基1,2,3,4四氢咔啉3羧酸(7);并采用SRB法对其抗肿瘤活性进行了测试,其中化合物2,3,5对温敏型小鼠乳腺癌细胞tsFT210显示弱的增殖抑制活性。
In order to find bioactive compounds,the secondary metabolites of the fermentation of actinomycete streptomyces sp. 3275 were studied, Among seven compounds were isolated from the active extract by repeated chromatography over silica gel, sephadex LH-20 column and HPLC. Their structures were identified on the basic of comparison to literature and spectroscopic analysis as cyclo （Val-Pro） （1）, cylco （Pro-Tyr） （2）, cyclo （Gly-Pro） （3）, cyclo （Pro-lie） （4）, cyclo （Leu-Pro） （5）, cholest- 5-en-3β- ol （ 6 ）, 1 -methyl- 1,2,3,4- tetrahydro- carboline-3-carboxylic acid （ 7 ）. Compounds 2,3,5 exhibited weak cytotoxicities against tsFIE10 cell line.
出处
《天然产物研究与开发》
CAS
CSCD
2006年第3期405-407,417,共4页
Natural Product Research and Development
基金
ThisresearcharefinanciallysupportedbyNational863Project(2003AA624020),NationalNaturalScienceFoundationofChina(No.30472136&30470196),QingdaoNaturalScienceFoundation(042JZ81).
关键词
海洋来源放线菌
链霉菌
次级代谢产物
抗肿瘤活性
marine-derived actinomycete
Streptomyces sp.
secondary metabolites
antitumor activity
作者简介
Corresponding author Tel： 86-532-82032065; E-mail： guqianq@ouc.edu. cn.
