摘要
目的 建立急性高原反应（acute mountain sickness，AMS）相关因素的多元线性回归模型，以预测AMS的发生。方法 在平原，对进藏人员用V max229D型肺功能仪测试肺功能；定量饮水后不同时间点测定累计尿量进行饮水试验；吸入低氧气体（10％ O2，90％ N2）10min进行低氧反应试验。空运进藏后，对AMS进行症状学评分。用逐步回归分析法建立多元线性回归模型。结果经相关分析，初选出受试者胸廓体积、用力肺活量、1s用力呼气容积、最大呼气流量（peak expiratory flow，PEF）和饮水1000 ml后1．5h内尿量、2h内尿量、2．5h内尿量及低氧反应7min时的心率是与AMS相关的危险因素，进一步经逐步回归，消除自变量间的共线性后，筛选出4个重要指标，得多元线性回归方程为：AMS评分=16．108－0．00304×（饮水1000 ml后2．5h内尿量）－0．441×PEF－0．0487×（低氧反应7min时的心率）－0．240×胸廓体积。回归效果检验的F值=5．889（P〈0．01）。结论 肺功能、饮水1000 ml后1．5－2．5h排出的尿量、低氧反应7min时的心率及胸廓体积可作为预测AMS发生与否的重要参考指标。
Objective To analyze the physiological factors related to acute mountain sickness （AMS） and establish a multiple line regression model to predict the AMS. Methods A total of 113 men aged （ 19 ± 1 ） years were enrolled in this study. At 300 m above sea level, the pulmonary function by Vmax 229D spirometer, the physiological responses to hypoxia via breathing mixed gas （ 10%O2 and 90% N2 ） for 10 min, the amount of urine at different time points after fast drinking 1 000 ml water, the responses of breath holding, serum cortisol by RIA, chest volume etc. were investigated. The symptomatic scores of benign form of AMS were calculated on day 2, 3 after the subjects arrived at Lhasa （3 658 m above sea level）. Multivariate linear regression analysis was used to check out the factors related to AMS. Results The chest volume, forced vital capacity, forced expiratory volume in 1 s, peak expiratory flow （ PEF）, the amount of urine within 1.5 h, 2 h and 2.5 h after fast drinking 1 000 ml water, and the heart rate at 7th min during breathing hypoxic gas were found related to AMS. The model of AMS prediction was as follow ： scores of AMS = 16. 108 - 0.003 04 × （ the amount of urine within 2.5 h after drinking 1 000 ml water） -0. 441 × PEF -0.048 7 x （the heart rate at 7th min during breathing hypoxic gas） - 0. 240 × chest volume. Of this equation, F = 5.889 （P 〈 0.01 ）. Conclusion Lung function, urine excretion after drinking 1 000 ml water, the heart rate at 7^th min during hypoxia and the chest volume are to be considered as the factors for AMS prediction.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2006年第12期1269-1272,共4页
Journal of Third Military Medical University
基金
全军医学科学技术研究"十五"计划指令性课题(01L062)~~
关键词
高原
低氧反应
急性高原反应
预测模型
线性回归
high altitude
hypoxia
acute mountain sickness
prediction
multivariate regression.
作者简介
黄庆愿（1967-），男，山东省莱芜市人，博士，副教授，主要从事缺氧病理生理方面的研究，发表论文15篇。电话：（023）68752340-8016，E-mall：wqyhang@yahoo．com
高钰琪,通讯作者：电话：（023）68752331，E-mail：gyq@mall．tmmu．com．cn
