摘要
目的探讨雌激素对宫缩乏力性产后出血的临床治疗效果。方法选择宫缩乏力性产后出血病例112例,随机分为实验组(52例)和对照组(60例),实验组在常规促宫缩治疗后随即肌肉注射苯甲酸雌二醇4mg,容积法计算产后出血量。结果(1)胎儿娩出后2h出血量比较:实验组产后出血量平均为(589.6±226.4)ml,明显低于对照组(864.5±359.5)ml(P<0.05);(2)胎儿娩出后2-24h出血量比较:实验组平均出血量(110.8±76.2)ml,对照组(剔除3例子宫切除病例)(161.5±98.3)ml,二者比较无显著性差异;(3)实验组未发生子宫切除病例,对照组子宫切除3例;(4)两组产妇和新生儿均未出现明显副作用。结论雌激素配合促宫缩药物治疗宫缩乏力性产后出血,对促进子宫收缩可发挥一定的协同作用,具有临床应用价值。
Objective To investigate the clinical efficacy of estrogen in management of postpartum hemorrhage due to uterine atony. Methods Totalling 112 puerperants with postpartum hemorrhage due to uterine atony were randomly assigned into 2 groups and received routine managements for uterine atony such as uterine massage and uterotonics administration. The puerperants in one group （n=52） was treated with 4 mg estradiol benzoate injected intramuscularly, and the amount of blood loss 2 h after delivery and between 2 and 24 h after delivery was recorded. Results There were significant differences in vaginal blood loss at 2 h after delivery between the 2 groups （P〈0.05）. The puerperants with estrodiol benzoate treatment had blood loss of 589.6±226.4 ml at 2 h and 110.8±76.2 ml within 2-24 h after delivery, which were both less than those in the control group （864.5±359.5 ml and 161.5±98.3 ml, respectively）. Postpartum hysterectomy was performed in 3 cases of the control group while none in estradiol benzoate-treated group. In the mothers and neonates, no major adverse effects were observed. Conclusion Estrogen shows cooperative efficacy with uterotonics in stimulating uterine contraction for managements of postpartum hemorrhage due to uterine atony, and can be of value in clinical application.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2006年第6期865-866,共2页
Journal of Southern Medical University
关键词
产后出血
雌激素
苯甲酸雌二醇
postpartum hemorrhage
estrogen
estradiol benzoate
作者简介
周沫（1955-），女，主任医师，研究方向：围生医学，电话：020-83827812-61722
