摘要
目的:探讨乳腺癌肿瘤淋巴管生成与肿瘤转移的关系。方法:免疫组织化学SP法进行VEGFR-3染色标记89例原发性乳腺癌肿瘤淋巴管。结果:所有病例均有不同程度淋巴管生成,但以肿瘤间质组织中淋巴管生成为主,癌巢中未见明显的成形淋巴管。肿瘤淋巴管密度与乳腺癌临床分期和腋淋巴结转移呈正相关,临床分期越晚,肿瘤淋巴管密度越高(P<0.05);腋淋巴结转移组的肿瘤淋巴管密度比无淋巴结转移组高(P<0.05)。结论:乳腺癌淋巴管密度与腋淋巴结转移呈正相关,淋巴管生成主要发生在肿瘤间质组织中。
Objective：To investigate the relationship between lymphangiogenesis in primary breast cancer and tumor metastasis. Methods： Immunohistochemistry SP method was applied to label the lymphatic vessels of tumors by VEGFR-3 staining in 89 cases of primary breast cancer. Results： Different levels of lymphangiogenesis took place, and it was mainly located in the paraneoplastic stroma. No evidence of mature lymphatic vessels was found in cancer nests. The lymphatic vessel density （LVD） of primary breast cancer tumor showed a positive correlation with the clinical stage and axillary lymph node metastasis. More advanced clinical stage tumors had higher LVD （P〈0.05）, and the LVD in the positive axillary lymph node group was significantly higher than in the negative group （P〈0.05）. Conclusions： Lymphangiogenesis is significantly correlated with axillary lymph node metastasis, and it predominantly takes place in the tumor stroma of primary breast cancer. The author believes that tumor lymphatic vessels are in essence the lymphatic vessels of the tumor stroma.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2006年第11期601-604,共4页
Chinese Journal of Clinical Oncology
基金
湖南省社会发展科技基金资助(编号:OISSY2008-41)
关键词
乳腺癌
VEGFR-3
淋巴管生成
转移
Breast cancer lymphatic vessels of the tumor stroma. VEGFR-3 Lymphangiogenesis Metastasis
作者简介
通讯作者：黄俊辉，hjh@xysm．net。
