摘要
目的探讨人食管鳞癌中ERK1和P38蛋白的表达情况。方法应用免疫组织化学方法检测35例人中晚期食管鳞癌及其癌旁正常黏膜(其中15例包括早期癌)中有丝分裂原活化蛋白激酶(MAPK)家族成员ERK1和P38的表达情况。结果ERK1和P38在中晚期鳞癌中的表达高于早期癌和正常黏膜,有统计学差异(P<0.01),P38的表达与性别、肿瘤大小、肿瘤位置及临床分期无明显相关(P>0.05),与有无淋巴结转移相关(P<0.01),ERK1的表达与上述临床病理特征无明显相关(P>0.05)。结论中晚期食管鳞癌中ERK1和P38处于过度表达状态,参与食管癌的发生、发展和转移。
Objective To investigate ERKI and P38 protein expressions in human esophageal squamous cell carcinoma. Methods The samples were obtained from 35 eases with the disease. The expressions of MAPK family members： ERK1 and P38 protein were detected by immunohistoehemistry, using the SABC staining method at the two sites： metaphase and anaphase carcinoma tissues and its paraneoplastie tissues of 20 cases ,and at three sites： metaphase and anaphase carcinoma tissues ,early carcinoma and paraneoplastic tissues of 15 cases. Results The expressions of ERKI and P38 protein in metaphase and anaphase cancer were higher than those in early carcinoma and the paraneoplastie tissues（ P 〈 0.05 ）, the expressions of P38 protein were correlated with stage（ P 〈 0.05）, and local lymph node involvement（ P 〈 0.05）, but not with gender, site or size of tumor（ P 〉 0.05） ： while the expression of ERK1 wasn＇t correlated with the clinical and pathologic characters. Conclusions ERK1 and P38 protein expressed more in human metaphase and anaphase esophageal squamous cell carcinoma, they may play important roles in the occurrence and development of esophageal cancer.
出处
《肿瘤基础与临床》
2006年第3期177-179,182,共4页
journal of basic and clinical oncology
基金
教育部"十五"211工程重点建设项目:肿瘤与生物工程(教重办[2002]第2号)资助
作者简介
通讯作者：赵立群，女。研究员，研究方面：消化道肿瘤癌变机理研究。E-mail：Liqunzhao@msn．com
