摘要
目的为了提高对儿童重症渗出性多形红斑(EEMM)的临床认识,提高治愈率。方法回顾性分析32例儿童重症渗出性多形红斑的临床症状及实验室检查资料。结果32例患儿均有EEMM典型临床表现,黏膜受累较重,男∶女为1.4∶1,平均年龄6.7岁。其中5例做了T细胞亚群抗原测定,CD3,CD4和CD8均下降,3例患儿行皮损组织病理检查,示基底细胞液化变性空泡改变,真皮浅层淋巴细胞为主浸润。结论儿童EEMM是一种少见的疾病,临床上具有特征性,去除病因,及时控制感染,早期应用足量、短程皮质类固醇激素可提高治愈率,联合应用大剂量丙种球蛋白可以提高疗效,减少后遗症。
Objective To further realizing the clinical features of Erytherma exudativum muhiforma major in child and improve the cure rate. Methods Clinical and data of lab analysis of 32 patients with Child Erytherma exudativum multiforma major had been investigated retrospectively. Results All of children had typical clinical symptoms of EEMM ,mucosa injured seriously , the ratio of male to female was 1.4： 1 ,the average age of onset was 6.7 years. 5 patients did the examinations of subgroup of T cell showed the decline of CD3 ,CIM and CDS. 3 patients the changes of histopathology displayed keratinocyte necrosis in epidermis and basal vacuolization. It was found that perivascular lymphocytic infiltration was in the upper dermis. Condusion EEMM was a rare diseases,it is clinical characteristics, do away with cause of disease , control infection. Early short-term of use corticosteroids showed promising rate of cure ,The additional IVIG reponse to improve effect and reduce sequel.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2006年第5期281-282,287,共3页
The Chinese Journal of Dermatovenereology
关键词
重症渗出性多形红斑
儿童
Erythema exudativum multiforma major
Child
作者简介
程颖（1972-）,女,上海市人,医学学士,主治医师,主要从事皮肤病临床工作.
