摘要
目的探讨MR扩散加权成像在肾功能评价中的价值。方法健康志愿者15例作为对照组,慢性肾病(chron ic k idney d isease,CKD)患者32例(其中肌酐正常组12例,肌酐升高组20例)作为研究组。分别测量各例的表观扩散系数(apparent d iffusion coeffic ient,ADC)并与血清肌酐水平及肌酐清除率对比分析。结果15例志愿者在扩散敏感梯度系数(b值)取50、100、400 s/mm2时平均ADC值分别为(405.366±35.964)×10-5mm2/s、(339.646±23.059)×10-5mm2/s、(254.532±13.676)×10-5mm2/s。CKD组病例中肌酐正常组分别ADC值为(336.622±12.879)×10-5mm2/s、(308.142±20.998)×10-5mm2/s、(211.398±14.604)×10-5mm2/s,肌酐升高组分别为(307.717±84.930)×10-5mm2/s、(265.415±57.754)×10-5mm2/s、(201.672±26.411)×10-5mm2/s,ADC值均低于正常对照组(肌酐正常组与正常对照组比较的t值分别为9.720、5.190、11.093,P值均<0.05;肌酐升高组与正常对照组比较的t值分别为6.533、7.382、10.864,P值均<0.05)。肌酐升高组病例的平均血清肌酐水平为(828.490±699.350)μmol/L,肌酐升高组病例的ADC值与血清肌酐水平负相关,但无统计学意义(b值分别为50、100、400 s/mm2时相关系数分别为-0.272、-0.283、-0.023,P值均>0.05)。肌酐升高组病例的平均肌酐清除率为(15.405±14.541)m l/m in,该组病例的ADC值与肌酐清除率呈弱正相关(b值分别为50、100、400 s/mm2时相关系数分别为0.511、0.430、0.335,P值均<0.05,ADC值与肌酐清楚率呈正相关,但相关关系不密切)。结论对肾脏进行扩散加权成像及ADC值测量是1种有一定潜力且无创的肾功能评价的手段。
Objective To evaluate the value of diffusion-weighted MRI in the functional study of kidney. Methods Fifteen volunteers as control group and 32 patients with chronic kidney disease （CKD） were underwent DW MR imaging in a dehydrated state. In CKD group, 12 cases were with normal serum creatinine （Scr） level （ CKD group 1 ） and 20 cases with Scr increased in different level （ CKD group 2 ）. Apparent Diffusion Coefficient （ADC） value of each kidney of all groups was measured and compared of their relationships with clinical data. Results The ADC values of 15 volunteers in different b values （50, 100, 400） were （405.366 ± 35.9639） ×10^-5 mm^2/s, （339.646 ± 23.0594） ×10^-5 mm^2/s and （254.532±13.6763） × 10^-5mm^2/s, respectively. The ADC values of CKD group 1 were （336.622 ± 12. 879） ×10^-5 mm^2/s , （ 308. 142 ± 20. 998 ） ×10^-5 mm^2/s, and （ 211. 398 ± 14. 604） ×10^-5 mm^2/s, respectively. And of CKD group 2 were （307. 717 ±84. 930） ×10^-5 mm^2/s （265.415 ±57. 754） ×10^-5 mm^2/s, and （201. 672 ±26.411） ×10^-5 mm^2/s respectively. The ADC values in CKD group were lower than those of the normal kidneys （ t values compared between the control group and CKD group 1 were 9. 720, 5. 190, 11. 093 separately, between the control group and CKD goup 2 were 6. 533, 7. 382, 10. 864 separately in different b values, with all P values less than 0. 05 ）. In CKD group 2, it had been showed negtive correlation between the level of Scr and ADC values of kidney, with mean level of Scr of （828. 490 ± 699. 350） μmol/L, but this was confirmed of no statistical meanings （the coefficient correlation were -0. 272,- 0. 2834 -0. 023 separately in different b values, with p values more than 0. 05 ）. For the creatinine clearance rate（ Cer）, it showed a weak positive correlation with ADC values of CKD group 2 （ the coefficient correlation were 0. 511,0. 430 0. 335 separately, with P values less than 0. 05 ）. Conclusion Diffusion-weighted MRI imaging and in vivo measurement of ADC values have the potential for use as a noninvasive means to explore the functional status of the kidney.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2006年第5期518-521,共4页
Chinese Journal of Radiology
关键词
磁共振成像
肾功能试验
对比研究
Magnetic resonance imaging
Diffusion
Renal function test
Comparative study
