摘要
目的研究脑梗死患者血清同型半胱氨酸(homocysteine,Hcy)水平及其与颈动脉硬化的关系。方法收集230例脑梗死患者、180例健康对照者血液标本,采用荧光偏振免疫法测定Hcy、叶酸和维生素B12及酶法测定血脂水平。同时对165例患者作颈动脉超声检查并按动脉硬化的程度分组,比较不同程度颈动脉硬化组血清Hcy水平变化。结果脑梗死组患者血清Hcy水平显著高于对照组(P<0.05),血清Hcy与叶酸,维生素B12呈明显负相关(P<0.05),随着颈动脉病变程度加重血清Hcy水平呈上升趋势,且高Hcy检出率增高。结论高Hcy血症是脑梗死的独立危险因素,与颈动脉硬化程度有关,高血Hcy水平的主要原因可能与缺乏叶酸、维生素B12有关。
Objective TO Study the level of serum homocysteine in patients with cerebral infarction and relationship between homoeysteine （Hey） and carotid artery atherosclerosis. Methods Blood sample were collected from 230 patients with cerebral infarction and 180 healthy individual controls. The concentrations of Hey, foliate and vitamin B12 were tested by means of fluorescence polarization immunoassay, plasma lipid was detected by enzymic method. In the meantime, all carotid arteries of 165 cases were examined with color Doppler ultrasound. The subjects were divided into 4 groups according to the severity of lesion of carotid artery. The concentration of Heys were compared in different groups. Results The level of Hey in the patients with cerebral infarction increased signii＇ieantly as compared with the controls （P〈 0. 05 ）, Hey was negatively correlated between foliate and vitamin B12 （P〈0. 05）. When lesion of carotid artery became severer, serum Hey was higher and more eases of hyperhomoeysteinemia were found. Conclusions Hyperhomoeysteinemia is a independent risk factor of cerebral infarction and is associated with carotid artety atherosclerosis. The cause of hyperhomocysteinemia may be associated with shortage of foliate and vitamin B12.
出处
《中国神经免疫学和神经病学杂志》
CAS
2006年第3期166-168,共3页
Chinese Journal of Neuroimmunology and Neurology
基金
山西省教育委员会科技基金资助项目(2001-13)
关键词
同型半胱氨酸
脑梗死
颈动脉硬化
叶酸
维生素B12
homoeysteine
cerebral infaretion
carotid artery atherosclerosis
foliate
vitamin B12
作者简介
王荔（1964-）,女，山西省人，硕士，副主任医师，主要从事脑血管病及神经系统感染性疾病的研究．通讯地址。山西医科大学第二医院神经内科，太原030001。联系电话：（0351）3365204．
