摘要
目的:采用RP-HPLC法考察4℃、25℃、37℃下24 h内奥硝唑注射液与注射用头孢噻肟钠的配伍稳定性。方法:采用Shimpack ODS色谱柱(4 mm×150 mm,5μm),流动相为甲醇∶水(60∶40),流速为0.5 mL/min,柱温25℃,检测波长为294 nm。结果:含奥硝唑50μg/mL和头孢噻肟钠100μg/mL的配伍液在4℃8 h、25℃4 h、37℃1 h内,外观及pH值无明显变化,奥硝唑的含量变化在5%以下,头孢噻肟钠的水解速率符合一级反应规律。结论:奥硝唑注射液与注射用头孢噻肟钠的配伍液在配伍后4℃8 h内、25℃4 h内、37℃1 h内可使用。
Objective： To evaluate the stability of compatibility of ornidazole injection and eefotaxime sodium for injection at 4℃, 25℃ and 37℃ for 24 h by RP-HPLC method. Methods： A Shimpack ODS column （4mm×150mm, 5μm） was used. The mobile phase was methanol water （60：40）. The flow rate was 0.5 mL/min. The column temperature was 25℃ and the UV detection wavelength was 294 nm. Results： There were no significant changes in appearance and pH value of the compatible solution containing 50μg/mL ornidazole and 100μg/mL cefotaxime sodium at 4℃ for 8 h, 25℃ for 4 h and 37℃ for 1 h. The content of ornidazole decreased by less than 5% and the hydrolytic reaction rate of cefotaxime sodium conformed to the first order reaction kinetics. Conclusion： The mixture of ornidazole injection and cefotaxime sodium for injection can be used after storing at 4℃ for 8 h, 25℃ for 4 h and 37℃ for 1 h.
出处
《药学服务与研究》
CAS
CSCD
2006年第2期136-138,共3页
Pharmaceutical Care and Research
关键词
奥硝唑
头孢噻肟钠
配伍
色谱法
高压液相
药物稳定性
ornidazole
ceiotaxime sodium
compatibility
chromatography, high pressure liquid
drug stability
作者简介
徐济萍（1961-），女（汉族），副主任药师 E-mail：xjp610510@163．com
