摘要
目的评价纳洛酮对脑外伤的早期疗效及C-反应蛋白(CRP)检测在纳洛酮治疗脑外伤中的应用价值。方法将68例重型脑外伤病人随机分为治疗组30例和对照组38例,对照组给予常规治疗,治疗组在常规治疗的基础上,给予纳洛酮0.4mg·kg-·1d-1治疗。观察病人的GCS评分、颅内压及头颅CT所示脑水肿的变化,并测定治疗前后血清CRP浓度。结果治疗组在提高GCS评分、降低颅内压、控制脑水肿等方面均明显优于对照组(P<0.01)。两组治疗前CRP分别为(73.64±8.64)mg/L(、69.23±7.31)mg/L,差异无统计学意义(P>0.05);治疗后治疗组为(37.25±11.45)mg/L,对照组为(48.54±12.07)mg/L,治疗组明显低于对照组(P<0.01)。结论①纳洛酮综合治疗脑外伤效果明显。②CRP可作为颅脑外伤病情及纳洛酮治疗效果判断的参考指标。
Objective To evaluate the therapeutic effect of early administration of naloxone and the possibility of C-reactive protein （CRP） as an index for estimating the effect of naloxone in the patients with traumatic brain injury. Methods Sixty-eight patients with severe brain injury were randomized into two groups： naloxone （0.4 mg .kg^-1 .d^-1） treatment group （n = 30） and control group （n = 38）, The recovery of patients was evaluated by Glasgow Coma Scale（GCS）, intracranial pressure （ICP） and brain edema change by CT scan ,while the serum concentration of CRP was detected before and after the treatment. Results Naloxone group showed significant difference as compared with control group in GCS, ICP and brain edema （P〈 0.01） after treatment. Serum CRP was （73.64±8.64）mg/L in the naloxone group, and （69.23±7.31）mg/L in control group, showing no significant difference between two groups （P 〉 0.05）, Pretreatment concentration of serum CRP was （37.25±11.45）mg/L in the naloxone group, and （48.54±12.07）mg/L in control group, showing a significant between the group difference（P 〈 0.01）. Conclusions Naloxone administration provides an effective therapy for traumatic brain injury, CRP can serve as an index for estimating the degree of traumatic brain injury and the effectiveness of naloxone treatment.
出处
《中国微侵袭神经外科杂志》
CAS
2006年第4期157-159,共3页
Chinese Journal of Minimally Invasive Neurosurgery
关键词
颅脑损伤
纳洛酮
C反应蛋白
craniocerebral
trauma naloxone
C-reactive protein
作者简介
张永明（1976-），男，江苏盐城人，南方医科大学附属南方医院在读硕士，主治医师。研究方向：颅底肿瘤、颅脑外伤的基础与临床
