摘要
目的探讨替米沙坦与氯沙坦治疗原发性高血压的疗效及安全性。方法将122例原发性高血压患者随机分为替米沙坦治疗组62例与氯沙坦治疗组60例,两组疗程均为8w。治疗前与疗程结束时分别采用美国产DP5000A动态血压监测系统进行24h动态血压监测分析。结果两组治疗前与治疗后24h、白昼与夜间平均血压均显著降低(P<0.01);治疗后替米沙坦组24h和夜间平均血压下降较氯沙坦组更显著(P<0.01);两组降压谷/峰比率分别为80.5±7.4%和62.8±4.3%,差异有极显著性(P<0.01)。结论替米沙坦是一种强效、安全、耐受性好的治疗高血压的良药。
Objective To explore the efficacy and safety of telmisartan vs. losartan in primary hypertension. Methods 122 patients with primary hypertension were randomly divided into group 1（n= 62） and 2（n= 60） for 8 weeks. 24h dynamic pressure monitors were conducted using DP5000A Ambulatory blood pressure monitoring system made in U. S. A. before and after treatment respectively. Results Compared with pretreatment or daytime, mean pressures within 24h after treatment or at night fell significantly of both 2 groups（P〈0.01）, those of research group fell more significantly than that of control group did（P〈0. 01）. Ratios of depressurization vallecula/peak of the 2 groups were 80.5±7.4% and 62.8±4.30%,diffrence was more significant（P〈0.01）. Conclusion Telmisartan is a potent, safe and well-tolerated drug in hypertension.
出处
《临床心身疾病杂志》
CAS
2006年第2期115-116,共2页
Journal of Clinical Psychosomatic Diseases
关键词
高血压
替米沙坦
氯沙坦
动态血压监测仪
Hypertension
telmisartan
losartan
Ambulatory blood pressure monitoring system
