摘要
【目的】探讨血浆胃泌素(Gas),胃动素(Mot)在门脉高压性胃病(PHG)中的水平及意义。【方法】应用放射免疫法测定42例PHG患者和32例无PHG肝硬化(NPHG)患者血浆Gas和Mot含量,并与20例正常人进行比较。【结果】PHG患者血浆Gas和Mot水平均显著高于NPHG患者和正常人(P<0.05),且随食道静脉曲张(EV)程度加重而升高,与门脉内径呈正相关(r=0.604,P=0.021);轻、重度PHG患者血浆Gas和Mot水平相比较差异均有显著性(P<0.05)。【结论】血浆Gas和Mot在肝硬化PHG的发生发展中起一定的作用,其水平可作为预测PHG的发生及了解PHG病变严重程度的一个参考指标。
[Objective]To explore the change and significance of plasma gastrin and motilin in the patients with portal hypertension gastropathy（PHG）. [Methods]The levels of plasma gastrin and motilin of 42 patients with PHG,32 patients without PHG and 20 healthy adults were measured with methods of radio-immunity. [Results]The plasma levels of gastrin and motilin in eases with PHG were significantly higher than those without PHG and healthy adult （ P〈0.05）, and increased with the severity of esophageal varix and positively correlated with internal diameter of portal vein. （r=0. 604, P =0. 021）. The plasma levels of gastrin and motilin in PHG of light ,moderate and high degree also showed significant difference from each other（ P 〈0.05）. [Conclusion]The plasma gastrin and motilin have effect on the development of PHG with liver cirrhosis,and the levels of plasma gastrin and motilin can be indexes for predicting the development of PHG and evaluating the severity of PHG. They may be significant to guide the clinical therapy.
出处
《医学临床研究》
CAS
2006年第4期491-493,共3页
Journal of Clinical Research
