摘要
目的探讨疣状胃炎(VG)与胃癌的关系。方法用酶标法和放射免疫法测定50例VG伴肠化、50例VG不伴肠化患者胃液CEA(癌胚抗原)、β2-MG(β2-微球蛋白)含量,并与对照组Ⅰ(不伴肠化的浅表性胃炎患者)、Ⅱ(伴肠化的浅表性胃炎患者)比较。结果胃液CEA浓度在VG伴肠化、不伴肠化组较对照组Ⅰ明显升高,差异有统计学意义(P<0.05)。VG伴肠化组较对照组Ⅱ胃液CEA浓度明显升高,差异有统计学意义(P<0.05)。胃液β2-MG浓度在VG伴肠化组、不伴肠化组较对照组Ⅰ明显升高,差异有统计学意义(P<0.05)。胃液β2-MG浓度在VG伴肠化组较对照组Ⅱ无明显升高,差异无统计学意义(P>0.05)。结论胃液CEA浓度可能与疣状胃炎癌前疾病有一定关系,测定胃液CEA对癌前疾病的监测和辅助诊断有一定临床的实用价值;测定胃液β2-MG对肠化癌前病变的监测和辅助有一定临床的实用价值。
Objective To study the relationship between gastric cancer and verrucosa gastritis （VG）. Methods Levels of carcinoembryonic antigen （CEA） and beta 2-microglobulin （β2-MG） in gastric juice were determined by radioimmunassay （RIA） and enzyme linked immunosorbent assay （ELISA） in 50 VG patients with intestinal metaplasia and 50 VG patients without intestinal metaplasia; and 100 patients with chronic superficial gastritis（CSG） were also studied as controls. Results The concentration of CEA in gastric juice was significantly higher in VG patients with intestinal metaplasia and VG without intestinal metaplasia than that of the patients with CSG patients without intestinal metaplasia （both P〈0.05） and the concentration of CEA in gastric juice was significantly higher in the VG patient with intestinal metaplasia than that of CSG patients with intestinal metaplasia （P〈0.05）. The concentration of β2-mG in gastric juice was significantly higher in VG patients with intestinal metaplasia and VG without intestinal metaplasia than that of CSG patients without intestinal metaplasia （both P〈0.05）, while the concentration of β2-MG was not different between VG with intestinal metaplasia and CSG with intestinal metaplasia （P〉0.05）. Conclusion The levels of CEA and β2-MG in gastric juice may be associated with precancerous lesions and intestinal metaplasia of VG.
出处
《浙江医学》
CAS
2006年第4期244-245,249,共3页
Zhejiang Medical Journal
关键词
疣状胃炎
肠化
癌胚抗原
Β2-微球蛋白
Verrucosa gastritis Carcinoembryonie antigen Bata2-microg lubulin Intestinal metaplasia
