摘要
【目的】观察早期智能干预促进中重度新生儿缺氧缺血性脑病（hypoxic—iscbemic encephalopathy，HIE）患儿智能发育、防治神经系统后遗症的远期效果。【方法】将同期住院的52例中重度HIE患儿随机分为早期干预组27例、对照组25例。两组接受相同的HIE常规治疗，干预组从生后7～10d开始接受早期智能干预。两组患儿均按双盲原则．于2岁时行Bayley婴幼儿发育量表（BSID）、5岁时行韦氏学龄前儿童智力量表（WPPSI）测试，以评价早期智能干预促进中重度HIE患儿神经康复的远期疗效。【结果】影响婴幼儿智能发育的有关生物学及环境因素分析，干预组与对照组比较差异无显著性（P〉0．05）。2岁时Bayley智测。干预组心理发展指数和运动发育指数显著高于对照组（P均〈0．05）。5岁时WPPSI智测．干预组总智商、言语智商和操作智商均显著高于对照组（P均〈0．05）。【结论】早期智能干预可促进中重度HIE患儿智能发育，促进神经康复．明显改善患儿的远期预后。
[Objectives] To study the long-time effect of early intellectual intervention on intellectual development of infants with moderate and severe hypoxie-ischemic encephalopathy（HIE）. [Methods] 52 infants with moderate and severe HIE were randomly divided into early intervention group （n=27） and control group （n=25）. The infants of the intervention group received early intellectual intervention begining at the age oT 7- 10 days. All infants in two groups received the same routine treatment during neonatal period. They received Bayley scale of infant development （BSID） test at the age of 2 years, Wechsler preschool and primary scale of intelligence （WPPSI）test at the age of 5 years. The intelligence tests were double blind. [Results] There was no significant difference in biological and environmental factors between inter- vention and control groups. At the age of 2 years, the average score of mental development indexs （MDI） and psychomotor mental development indexs（PDI）of BSID in intervention group were significantly higher than those of the control group （t =2. 34,2.06; P〈0.05）. At the age of 5 years the average score of full-scale intelligence quotient（FIQ） , verbal intelligence quotient （VIQ） and performance intelligence quotient（PIQ） of WPPSI in intervention group were significantly higher than those of the control group（t=2.03-2.23;P〈0.05）. [Conclusion] Early intellectual intervention can improve intellectual development of infants with moderate and severe HIE,and can significantly improve their long-term prognosis.
出处
《中国儿童保健杂志》
CAS
2006年第2期150-152,共3页
Chinese Journal of Child Health Care
关键词
缺氧缺血性脑病
新生儿
智力
早期干预
hypoxle-ischemic encephalopathy
neonate
intelligence
early intervention
作者简介
姜红（1964-），女，山东人。副教授。硕士研究生导师，博士学位。主要从事新生儿脑损伤及干预研究。
