摘要
目的:探讨阿奇霉素治疗小儿支原体肺炎的疗效及安全性。方法:112例支原体肺炎患儿随机分成治疗组和对照组各56例。治疗组给予阿奇霉素10mg/(kg.d)静脉滴注,1次/d,疗程5￣7d;对照组给予红霉素30mg/(kg.d)静脉滴注,2次/d,疗程7￣14d。结果:治疗组退热时间、咳嗽好转时间、啰音消失时间和平均住院时间均较对照组短,局部疼痛、胃肠道不良反应及肝功能损伤程度明显低于对照组,差异均有统计学意义(P<0.05)。结论:阿奇霉素治疗小儿支原体肺炎效果显著,疗程短,不良反应少,值得临床推广。
Objective： To evaluate the therapeutic effect and safety of azithromycin on children＇s mycoplasma pneumonia. Methods： 112 children with mycoplasma pneumonia were divided randomly into treatment group and control group, with 56 cases per group. The treatment group were given a daily dose of 10 mg/（kg·d） of azithromycin administered by IV instillation for 5 - 7 days for each patient. The patients of the control group were given a daily dose of 10 mg/（kg·d） of erythromycin administered by IV instillation for each. The course of treatment in both groups lasted 7 - 14 days. Results： The pyretolysis time, cough improvement time, rale disappearing time and the mean length of hospitalization of treatment group were shorter than that of control group. The local ache, stomach and intestinal tract adverse reaction, and damage of hepar function were less than those in control group. The difference was remarkable （P 〈 0.05）. Conclusions： Using azithromycin in children＇s mycoplasma pneumonia can get better therapeutic effect and shorter period of treatment with less adverse reaction.
出处
《儿科药学杂志》
CAS
2006年第2期42-43,共2页
Journal of Pediatric Pharmacy
关键词
阿奇霉素
儿童
支原体
肺炎
Azithromycin
Children
Mycoplasma
Pneumonia
