胰岛素受体在多囊卵巢综合征患者子宫内膜的表达与调控被引量：14

Expression of insulin receptor protein in endometrium of patients with polycystic ovary syndrome

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摘要目的探讨胰岛素受体在多囊卵巢综合征(PCOS)患者子宫内膜的表达与意义。方法用免疫组织化学的方法检测44例PCOS患者与28例对照组子宫内膜胰岛素受体蛋白的表达。结果胰岛素受体蛋白在PCOS增殖期与对照组增殖期子宫内膜的表达差异无统计学意义,PCOS子宫内膜增殖症的腺上皮细胞表达显著高于PCOS增殖期以及对照组增殖期,PCOS分泌期子宫内膜的表达低于对照组分泌期。结论增加的胰岛素受体与超生理剂量的胰岛素结合可能是导致子宫内膜的异常增生的原因之一;胰岛素受体可能参与子宫内膜的转化。 Objective To study the expression and role of insulin receptor protein in endometrium of patients with polycystic ovary syndrome. Methods The expression of insulin receptor protein in endometrium from 44 PCOS and 28 normal controls was measured by immunohistochemical method. Results There was no significant difference between the control group and PCOS group in proliferation.Insulin receptor protein showed weak staining in the cell of PCOS secretary phase endometium; Compared with the control, there were strongly positive staining in the glandular cells of abnormal hyperplasia endometrium. Conclusion Hyperinsulin binding increased insulin receptor may be an potential reason of the neoplastic transformation of endometrium.Iinsulin receptor could take part in endometrial transportation during secretary phase.

作者姜艳华陈咏健李美芝

机构地区山西省妇幼保健院妇产科北京医科大学第三医院妇产科

出处《中国药物与临床》 CAS 2006年第3期197-199,i0001,共4页 Chinese Remedies & Clinics

基金山西省卫生厅科技基金资助项目(200161)

关键词多囊卵巢综合征子宫内膜受体胰岛素 Polycystic ovary syndrome Endometrium Receptor,insulin

分类号 R711.75 [医药卫生—妇产科学]

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1Thiet MP,Osathanond R,Yeh J.Appearance of insulin,insulinlike growth factor -1,and their receptors in the human fetal mullerrian tract.Am J Obstet Gynecol,1994,170(1):152-156.
2Marsh MM.Immunolocalization of ET and neutral endopeptidase in the endometrium of users of subdermally implanted levonorgestrel.Hum Reprod,1995,10:2584-2589.
3李虹.胰岛素受体底物家族中的两个新成员[J].国外医学（分子生物学分册）,1999,21(5):292-295. 被引量：5
4Stowitzki T,Von eye HC,Keller M,et al.Tyrosine kinase activity of insulin-like growth factor-1 andi nsulin receptor in human endometrium during the menstrual cycle:cycle variation of insulin receptor experession.Fertil Teril,1993,59(2):315-321.
5Bershtein LM,Gamaiunova VB.The nature of hyperinsulinemia(insulin resistance) in endometrial carcinoma:of plasma levels of insulin and c-peptide.Vopr Onkol,2000,46(2):191-195.
6Randolph JF,Kipersztok S,Jonnathan WT,et al.The effect of insulin on aromatase activity in isolated human endometrial glands and stroma.Am J Obstet Gynecol,1987,157(6):1534-1539.
7陈咏健,魏兆莲,李美芝,王蔼明.多囊卵巢综合征患者子宫内膜细胞色素P450的表达[J].北京医科大学学报,2000,32(6):515-518. 被引量：7
8Nagamani M,Stuart CA.Specific binding and growth promoting activity of insulin in endometrial cancer cells in culture.Am J Obstet Gynecol,1998,179:6-12.