摘要
Objective： To investigate the mechanism of capsaicin in treating active psoriasis vulgaris. Methods： VIP protein in active psoriatic lesions before and 30 days after the treaanent of capsaicin ointment was detected by immunohistochemistry. Results： There was positive expression of VIP in all layers of psoriatic lesions epidermis （95.5 % ）, but after the treatment of capsaicin ointment, there was nearly no expression of VIP protein in epidermis（22.2% ）. Conclusion： Capsaicin inhibits proliferation and induces the differentiation of keratinocytes through down-regulating the expression of VIP in psoriatic epidermis.
Objective： To investigate the mechanism of capsaicin in treating active psoriasis vulgaris. Methods： VIP protein in active psoriatic lesions before and 30 days after the treaanent of capsaicin ointment was detected by immunohistochemistry. Results： There was positive expression of VIP in all layers of psoriatic lesions epidermis （95.5 % ）, but after the treatment of capsaicin ointment, there was nearly no expression of VIP protein in epidermis（22.2% ）. Conclusion： Capsaicin inhibits proliferation and induces the differentiation of keratinocytes through down-regulating the expression of VIP in psoriatic epidermis.
作者简介
Correspondence should bc addressed to chunshui Yu（e-mail：yuchsh91@sohu.com）
