摘要
目的观察丹栀逍遥散治疗抑郁症的临床疗效及不良反应。方法采用随机双盲对照方法,将63例患者分为两组,分别用麦普替林(西药组31例)和丹栀逍遥散(中药组32例)治疗,于用药前及用药2、4、6周时采用汉米尔顿抑郁量表(HAMD)、抑郁自评量表(SDS)、焦虑自评量表(SAS)及中医症状辨证量表等评定药物疗效,用Asberg副反应量表评定不良反应。结果两组临床疗效比较差异无显著性;两组治疗后HAMD、SDS和SAS积分均明显低于治疗前(P<0.05),但两组间比较差异无显著性;中医症状辨证量表评定两组间差异无显著性;Asberg副反应量表分值中药组低于西药组(P<0.05)。结论丹栀逍遥散治疗抑郁症疗效与麦普替林相当,而不良反应明显少于麦普替林。
Objective To observe the effect and side effect of Danzhi Xiaoyao powder （DXP） in treating depression, Methods A randomized controlled and double-blinded study was conducted in 63 cases of depression by divided them into the western medicine group （WMG, 31 cases） treated with maprotiline, and the Chinese medicine group （CMG, 32 cases） treated with DXP. The effect of therapy was evaluated before and at the 2nd, 4th and 6th week of the treatment with Hamilton＇s depressive scale （HAMD）, self-rating depression scale （SDS）, self-rating anxiety scale （SAS） and the scale for TCM syndrome and symptom differentiation （TCMSSD）, and the side-effect of therapy was assessed with Asberg side-effect scale as well. Results There was no significant difference between the two groups in scores of HAMD, SDS, SAS, and TCM-SSD. The markedly effective rate in CMG was 84 % and in WMG 87 %, showed no significance between them （P 〉 0.05）. The scores of HAMD, SDS and SAS of both groups were remarkably lowered after therapy （P 〈 0.05）. However, the score of Asberg in CMG was lower than that in WMG （P 〈 0.05）. Conclusion DXP shows the effect equivalent to that of maprotiline, but with obviously less side-effect.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2006年第3期212-214,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
教育部教育振兴行动计划特殊专项985一期
关键词
丹栀逍遥散
麦普替林
抑郁症
随机双盲对照研究
Danzhi Xiaoyao powder
maprotiline
depression
randomized double-blinded controlled study
作者简介
通讯作者：钱瑞琴，Tel：010-82801198，E-mail：qianruiqin@bjmu．edu．cn
