摘要
目的观察小剂量激素替代治疗(HRT)的应用及监测。方法观察更年期门诊117例围绝经期及绝经后妇女使用小剂量倍美力利维爱及安宫黄体酮治疗更年期相关症状及骨质疏松的效果,并通过B超等方法监测其安全性。结果通过3个月至5年的治疗,潮热出汗等症状均得到改善,骨质疏松或骨丢失者骨量丢失减缓,在治疗过程中未见子宫内膜增生,伴子宫小肌瘤者未见肌瘤增大。结论小剂量HRT应用于围绝经期及绝经后妇女的治疗是安全有效的。
Objective To observe the effect of low-dose of HRT in perimenopausal and postmenopausal women. Methods Fifty-two perimenopausal women, aged （48.5 ± 2.9） years and 65 postmenopausal women, aged（53.6 ± 6.0）years, were given low-dose of HRT for three months to five years. Livial 1.25 mg per day, or combined estrogen and progesterone containing conjugated equine estrogen（ CEE）0.3 mg per day, and medroxy progesterone acetate 1.25 mg（continuous combinations）or 2.5 mg per day were given respectively. Results For those women with primary complain of the vasomotor symptoms （hot flash, sleepless）, sleep disturbances and mood changes were ameliorated after low-does HRT and the bone loss was reduced as well. No changes in the endometrial thickness and other sideffects were detected post-therapy. Conclusions Low-dose HRT is effective in preventing and treating menopausal symptoms and osetoporosis.
出处
《中国骨质疏松杂志》
CAS
CSCD
2006年第1期59-61,共3页
Chinese Journal of Osteoporosis
关键词
激素替代治疗
小剂量
绝经
更年期
Hormone Replacement therapy（HRT）
Low-dose
Menopause
作者简介
通讯作者：杨池荪，Email：yangdf123456@126．com。
