摘要
Functional dyspepsia （FD） is a highly prevalent but heterogeneous disorder in which multiple pathogenetic mechanisms are involved. Although there are many studies that have investigated various pathophysiologic mechanisms, the underlying casual pathways associated with FD remain obscure. The currently proposed pathophysiologic mechanisms associated with FD include genetic susceptibility, delayed as well as accelerated gastric emptying, visceral hypersensitivity to acid or mechanical distention, impaired gastric accommodation, abnormal fundic phasic contractions, abnormal antroduodenal motility, acute and chronic infections, and psychosocial comorbidity. A greater understanding of the abnormalities underlying FD may lead to improved management. The aim of this editorial is to provide a critical overview of current pathophysiologic concepts in functional dyspepsia.
机能性消化不良(FD ) 是多重病原的机制涉及的高度流行却异构的混乱。尽管有许多研究，调查了各种各样的 pathophysiologic 机制，与 FD 联系的内在的随便小径仍然保持阴暗。与 FD 联系的当前建议的 pathophysiologic 机制包括基因危险性，推迟以及加速胃的倒空的、内脏的超敏性到酸或机械膨胀，损害胃的住所，反常底的的局面的收缩，反常 antro 十二指肠的活动性，急性、长期的感染，和精神分析社会 comorbidity。位于 FD 下面的畸形的更大的理解可以导致改进管理。这篇社论的目的是在机能性消化不良提供当前的 pathophysiologic 概念的批评概述。
作者简介
Correspondence to： Nicholas J Talley, MD, PhD, Professor of Medicine. Mayo Clinic College of Medicine, Plummer 6-56, 200 First Street S.W., Rochester, MN 55905, United States. alley.nicholas@mayo.edu Telephone： ＋1-507-266-1989 Fax： ＋1-507-538-7202
