摘要
目的探讨血清同型半胱氨酸(HCY)水平与颈动脉粥样硬化的相关性,以及与高血压、糖尿病、高脂血症等动脉粥样硬化性血管病(ASVD)危险因素的关系。方法选取住院患者97例,用酶联免疫吸附法(ELISA)测定血清HCY水平,用彩色多普勒超声仪行颈动脉壁内膜-中膜厚度(IMT)、动脉斑块积分检查。结果血清HCY水平与颈动脉IMT、动脉斑块积分呈正相关,与高血压、糖尿病、高脂血症无关。结论血清同型半胱氨酸水平与颈动脉粥样硬化密切相关,与高血压、糖尿病、高脂血症等动脉粥样硬化性血管病危险因素无直接关系,血清HCY水平是动脉粥样硬化的一个独立危险因素。
Objective To evaluate the relationship between serum homocysteine level and carotid artery atherosclerosis,and to evaluate the relationship between the serum homocysteine level and hypertension,diabetes, hyperlipoproteinemia. Methods Ninety seven patients were included, serum homocysteine level was measured with ELISA method,carotid artery intimal-medial thickness （IMT）and plaque integration were measured by color Doppler ultrasound. Results Serum homocysteine level were positively correlated to artery IMT and arteria plaque integration （r=0.3959, P〈0.001 ; and r=0.7474, P〈0.001, respectively ）.There was no correlation between serum homocysteine level and hypertension, diabetes and hyperlipoproteinemia. Conclusion Serum homoeysteine level were positively correlated with atherosclerosis of carotid artery. It was not correlated to hypertension,diabetes,hyperlipoproteinemia. Serum homocysteine level might be an important and independent risk factor to affect carotid atherosclerosis.
出处
《中国心血管病研究》
CAS
2006年第3期178-179,共2页
Chinese Journal of Cardiovascular Research
关键词
高半胱氨酸
颈动脉
动脉硬化
血管内膜
Homocysteine
Carotid arteries
.Atherosclerosis
Turica intima
