摘要
采用侧脑室插管法记录颅内压的技术，观察不同Ｇ值水平及增长率的＋Ｇｚ作用下兔颅内压变化。结果表明：（１）在增长率和峰值作用时间恒定时，麻醉兔在＋３、＋５及＋７Ｇｚ作用下，颅内压降低（Ｐ＜０．０１）。随Ｇ值增加，颅内压负值亦随之增大，呈显著负相关。当＋Ｇｚ解除，颅内压随之恢复，并呈现一过性升高，随后逐渐恢复正常，三种Ｇ值时的颅内压瞬时最高值无显著差异。（２）在Ｇ值和峰值作用时间恒定条件下，麻醉兔在０．１、１及３Ｇ／ｓ三种增长率的＋５Ｇｚ作用时，颅内压下降（Ｐ＜０．０１），三者之间无显著差异。随增长率增加，颅内压降低速率亦随之增加，颅内压降低速率与增长率呈显著正相关。三种增长率的＋Ｇｚ解除时，颅内压瞬时最高值无显著差异。提示，＋Ｇｚ暴露可引起兔颅内压瞬时剧烈变化，颅内压负值随Ｇ值的增加而增大，颅内压降低速率随Ｇ值增长率的增加而增加。颅内压的瞬时剧变可能是Ｇ－ＬＯＣ及＋Ｇｚ致脑损害发生机制的因素之一．
Change of intracranial pressure (ICP)under different levels of +Gz with differ-ent onset rates were investigatedin rabbits with intubation into lateral ventricles of the brain.The results were:1) While onset rate and duration were kept constant,ICP decreased dur-ing +3,+5and +7 Gz exposures.There was a negative linear correlation between ICP and+Gz level.There were no significant differences among the change rate of ICP[d(ICP)/dt] at the three + Gz levels. ICP increased temporarily immediately after + Gz expo-sure,then returned to normal gradually.(2) While + GZ level and duration were kept con-stant,ICP decreased during + 5 Gz exposures with 0.1,1 and 3 Gz/s onset rates.The de-creases were not significantly different among the three onset rates.There was a positive lin-ear correlation between d(ICP)/ dt and oriset rate.It suggests that the large,rapid fall in ICP during +Gz exposure may be an component in the overall mechanisms of G-LOC and +Gz induced brain damage.
出处
《航天医学与医学工程》
CAS
CSCD
1996年第2期86-91,共6页
Space Medicine & Medical Engineering
关键词
加速度
颅内压
兔
acceleration intracranial pressure rabbit
