摘要
目的研究苦参素与丹参注射液联合治疗对慢性乙型肝炎患者血清肝纤维化指标的影响。方法60例血清肝纤化指标明显异常的慢性乙型肝炎患者随机分为治疗组及对照组,治疗组给予丹参注射液静脉滴注,并同时给以苦参素口服;对照组给以护肝对症治疗。采用放射免疫法(RIA)测定治疗前后透明质酸(HA)、层粘蛋白(LN)、Ⅲ型前胶原(PCⅢ)和Ⅳ型胶原(ⅣC)等血清肝纤维化指标的变化。结果治疗组肝纤维化4项指标较对照组均有明显下降(P<0.01)。结论苦参素联合丹参注射液对慢性乙型肝炎所致肝纤维化有明显改善作用。
Objective To study the influence of oxy matrine combined with salvia mltlorrhiz on the hepatic fibrosis markers. Methods 60 patients with abnomal prameters of fibrosis level were randomly divided into two groups,30 patients of treatment group treated by salvia miltiorrhiz and oxy matrine, the control group was given liver protectiont treatment, then observed the changes of hepatic fibrosis markers： HA, LN, PC Ⅲ , and Ⅳ C. Results A significant decrease of HA,LN, PC Ⅲ , and Ⅳ C were observed in the patients treated with oxy matrine and salvia miltiorrhiz（P 〈0.01）. Conclusion The treatment of oxy matrine combined with salvia miltiorrhiz on hepatic fibyosis is useful.
出处
《中国基层医药》
CAS
2006年第1期70-71,共2页
Chinese Journal of Primary Medicine and Pharmacy
