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组织型纤溶酶原激活物在中枢神经损伤中的调节作用

The regulatory effect of tissue plasminogen activator involved in central nervous insult
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摘要 组织型纤溶酶原激活物(tPA)是目前临床上用于治疗急性脑卒中的首选药物,然而动物实验表明,在中枢神经系统内tPA可能通过促进小胶质细胞活化、促细胞外基质降解、增强N-甲基-D-天冬氨酸(NMDA)受体依赖性信号调节等途径促进兴奋性毒性诱导的神经元变性。也有研究指出,tPA能保护鼠神经元免于锌诱导的毒性损伤。本研究综述了近几年关于中枢神经系统中tPA的神经毒性与神经保护作用机制的研究进展。 Tissue plasminogen activator（tPA） had been used clinically as a choice drug for the therapy of ischemic nervous system（CNS） via the induction of microglial activation, degradation of laminin matrix and enhancement of the N-methyl-D-aspartate （NMDA） receptor-mediated signaling in neurons, other reports imply tPA could protect rat neuronal cells from zinc-induced toxicity.
作者 彭琳 霍霞 徐锡金
机构地区 汕头大学医学院中心实验室
出处 《医学研究生学报》 CAS 2006年第2期157-160,共4页 Journal of Medical Postgraduates
基金 广东省教育厅自然科学基金资助项目(批准号:Z03037)
关键词 组织型纤溶酶原激活物 兴奋性毒性 神经元变性 Tissue plasminogen activator Excitotoxity Neurodegeneration
分类号 R338.21 [医药卫生—人体生理学]
作者简介 彭琳（1980-），女，广东汕头人，医学硕士研究生，从事神经损伤与修复研究。
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参考文献18

  • 1Fermandez MM, Lopez-Atalaya JP, Benchenane K, et al. Is tissue-type plasminogen activator a neuromodulator? [ J ] Mol Cell Neurosci, 2004, 25(4):594-601.
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二级参考文献7

  • 1Indyk JA, Chen ZL, Tsirka SE et al. Laminin chain expression suggests that laminin-10 is a major isoform in the mouse hippocampus and is degeraded by the tissue plasminogen activator/plasmin protease cascade during excitotoxic injury [J]. Neurosci,2003, 116(2): 359-371.
  • 2Tsirka S, Rogove A, Bugge T et al. An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus [J]. J Neurosci,1997, 17(2):543-552.
  • 3Siao CJ, Fernandez SR, Tsirka SE. Cell type-specific roles for tissue plasminogen activator released by neurons or microglia after excitotoxic injury [J]. Neurosci,2003, 116(8): 359-371.
  • 4Rogove AD, Lu W, Tsirka SE et al. Microglial activation and recruitment, but not proliferation, suffice to mediate neurodegeneration [J]. Cell Death Differ,2002, 9(8): 801-806.
  • 5Rogove AD, Siao C, Keyt B et al. Activation of microglia reveals a non-proteolytic cytokine function for tissue plasminogen activator in the central nervous system [J]. J Cell Sci,1999, 112(22): 4007-4016.
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  • 7Tsirka SE. Clinical implications of the involvement of tPA in neuronal cell death [J]. J Mol Med,1997, 75(5):341-347.

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医学研究生学报
2006年 第2期

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