摘要
目的提出一种基于中药色谱指纹图谱和指标性成分含量进行中药提取物质量控制的混合优化方法。方法运用非线性规划方法,以指纹图谱相似度和多个指标性成分含量相对偏差为优化指标,建立中药提取物混合优化模型,采用逐步二次规划方法求得最优的混合比例。结果选择不同批次的丹参提取液作为混合优化典型研究对象,应用混合优化方法得到的混合提取物质量符合标准要求。结论混合优化方法可以提高批次间中药产品质量的稳定性。
OBJECTIVE To propose a new method based on Chinese medicinal chromatographic fingerprint and the contents of key constituents and apply the new method for the quality control of Chinese medicinal plant. METHODS A new blending optimization model of TCM＇s plant was built by a nonlinear programming method, and the optimization objective was the combination of fingerprint similarity and the relative deviation of the contents of multiple key constituents, and the optimal blending ratios was obtained by sequential quadratic programming method. RESULTS Several different batches of Danshen extracts were selected as typical research subjects, and a blend satisfied the quality criterion was obtained with the proposed method. CONCLUSION The proposed method can assure the batch-to-batch consistency of plant extracts.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2006年第1期57-60,共4页
Chinese Pharmaceutical Journal
基金
浙江省科技厅重大科技计划(021103549)
关键词
中药提取物
指纹图谱
混合优化
多指标性成分
plant extracts
chromatography fingerprint
blending optimization
multiple key constituents
作者简介
瞿海斌，男，教授
通讯作者：程翼宇，男，教授 Tel：（0571）87951138 E-mail：chengyy@zju．edu．cn
