摘要
糖尿病以慢性高血糖为主要共同特征,高血糖是心血管疾病进展的独立的危险因素。糖尿病人群中动脉粥样硬化性疾病的患病率高、发病年龄较轻、病情进展快、多脏器同时受累较多。高血糖致血管内皮受损是动脉粥样硬化的重要原因之一;因而增加胰岛β细胞数量、改善胰岛β细胞功能,降低血糖;保护血管内皮细胞;可抑制动脉粥样硬化的进展,减少糖尿病心血管并发症。而肝细胞生长因子(HGF)是由间质细胞产生的多效性生长因子,能刺激多种类型的细胞分化、增殖、运动、迁移、促进新生血管形成;在糖尿病及心血管并发症的诊断和治疗中具有重要作用。本文就HGF对胰岛β细胞、血管内皮细胞和在心肌梗死中的具体作用及机制综述如下。
The main feature of diabetes is glycemia which is an independent risk lector of the cardiovascular disease in progressive stage Atherosclerosis in patients with diabetes has high prevalence, attackso early, develops quickly, and effects multiple organs simul tanously. Injury of endothelial cells induced by glycemia is ane of important causes of the progression of atheroaclerosis in patients with cliabetes. Development of atherescleroeis and forma- tion of cardiovascular complication can be inhibited by enhancing the mount of islet β cells, improving the function of isletβ cells, decreasing hloed glucese, and protecting endothelial cells. Hepatecyte growth factor （HGF） is a masenchymal cells-derived multiple effect grouth factor, which is able to stimulate differentiation, proliferation, movement, migration of muhipld cells, and promote the fprmation of blood vessels. HGF has important role in diagnosis and therapy of diabetes and its complication.The action and mechanism of HGF in islet β cells,endothelial cells, and myocardial infarction are revwed in this article.
出处
《医学综述》
2006年第1期39-41,共3页
Medical Recapitulate
关键词
糖尿病
肝细胞生长园子
血管内皮细胞
心肌梗死
Diabetes
Hepatocyte grouth factor
Atherosclerosis
Endothelial cells
Myocardial infaretion
