摘要
目的探讨CYP2E1基因多态性与环境因素在胃癌发生中的交互作用。方法采用1∶1配对病例-对照研究方法,2003—2004年对南京地区121例原发性胃癌病例进行环境危险因素调查,并对CYP2E1基因多态性进行分析,筛选胃癌发生的环境及遗传危险因素,根据交互作用系数(γ,γ=βeg/βe)判断交互作用存在与否以及不同的基因-环境作用类型。结果CYP2E1RsaⅠ基因多态性与消化系统疾病家族史、吸烟、食用腌制食品、三餐不定时等4项环境危险因素间存在一定的交互作用,交互作用系数分别为1.855、2.626、1.736、1.714;CYP2E1RsaⅠ基因多态性与食用腌制食品及三餐不定时间的交互作用分别呈现低暴露-基因效应(lowexposure-geneeffect熏LEG效应)、高暴露-基因效应(highexposure-geneeffect熏HEG效应)。结论胃癌的发生是环境及遗传危险因素综合作用的结果。CYP2E1基因多态性与环境危险因素的暴露在胃癌发生中存在一定的交互作用。
Objective To study the interaction of genetic polymorphisms of CYP2E1 and environmental hazard factors in gastric cancer. Methods 1：1 case-control study was carried out in Nanjing area, using PCR-RFLP technology to determined the genetic polymorphisms of CYP2E1 and epidemiological data about environmental exposure of 121 cases and controls were collected. Interaction indexes （γ） were calculated to determine the type of gene-environment interaction. Results After confounding adjusted, the result showed that interaction existed in genetic polymorphisms of CYP2E1 Rsa I and the family history of digestive system disease, smoking, pickled food, irregular diet habit, interaction indexes （γ） value were 1.855, 2.626, 1.736 and 1.714 respectively. A low exposure-gene effect interaction was found in CYP2E1 Rsa Ⅰ genotype and the frequency of pickled food consumed, while a high exposure-gene effect interaction exist in CYP2E1 Rsa Ⅰ genotype and irregular diet habit. Conclusion Genetic and environmental hazard factors co-effect the development of gastric cancer, genetic polymorphisms of CYP2E1 and environmental risk factors show an interaction in gastric cancer.
出处
《环境与健康杂志》
CAS
CSCD
北大核心
2006年第1期7-10,共4页
Journal of Environment and Health
关键词
胃癌
基因多态性
环境危险因素
交互作用
Gastric cancer
Gene polymorphism
Environmental risk factors
Interaction
作者简介
张娇（1978-），女，助教，从事环境流行病学研究。
通讯作者：沈孝兵，Tel：（025）83272571
