摘要
[目的]探讨血清神经元特异性烯醇化酶(neuron-specific enolase,NSE)水平与非霍奇金淋巴瘤(non-Hodgkin’s lymphoma,NHL)的临床关系。[方法]采集40例的NHL患者初诊时和缓解后的全血2ml,离心后分离上层血清,使用化学发光荧光法检测血清NSE浓度。分析NSE与临床分期、有无B症状、年龄等临床指标的关系以及NSE升高组和正常组的生存期。[结果]40例NHL患者的血清NSE浓度为8.05ng/ml￣159.90ng/ml(平均浓度为29.85ng/ml),62.5%患者血清NSE浓度高于正常值上限(15.2ng/ml)。11例获得部分或完全缓解的患者治疗前和缓解后的血清NSE平均浓度分别为50.68ng/ml和9.36ng/ml,统计分析表明缓解前后血清NSE值差异具有显著性(t=2.491,P=0.032)。AnnArbor分期Ⅳ期患者血清NSE比Ⅰ￣Ⅲ期的明显增高(Z=2.584,P=0.009)。有B症状患者血清NSE比没有B症状的明显增高(Z=2.417,P=0.015)。血清LDH升高的患者的NSE明显高于血清LDH正常的患者(Z=2.587,P=0.009),且两者之间存在正相关(r=0.43,P=0.006)。血清NSE正常组1年生存率有高于NSE升高组的趋势(P=0.057)。[结论]血清NSE可以作为监测NHL治疗效果和估计预后的一个指标。
[Purpose] To study the clinical significance of serum Neuron-specific enolase （NSE） in patients with non-Hodgkin＇s lymphoma （NHL）. [Methods] The level of serum NSE in 40 NHL patients was assayed by electrochemiluminescence i,nmunoassay method. The relationship between serum NSE with clinical stage, B symptoms, age and survival ,＇ate was analyzed. [Results] The serum NSE vah.es in 40 patients was in the range from 8.05 ng/ml to 159.90 ng/ml （ mean value of 29.85 ng/ml）. Among these patients, the NSE values in 62.5% patients were higher than the cutoff value （15.2 ng/ml）. For the eleven patients who achieved ,remission, the mean serum NSE value at initial diagnosis was 50.68 ng/ml, and the corresponding value after remission was 9.36 ng/ml. Statistical difference was obtained in the NSE value before therapy and after remission （t= 2.491, P=0.032）. Serum NSE values of the patients with clinical stage IV were significantly higher than that of the patients with clinical stage Ⅰ-Ⅲ （Z=2.584, P=0.O09）. Serum NSE value in the patients with B symptoms significantly higher than that in the patients without B symptoms （Z= 2.417,P=0.015）. Serum NSE value in the patients with abnormal LDH level significantly higher than that in the patients with normal LDH level （Z=2.587, P=0.009）, with positive correlation （r= 0.43, P=0.006）. There was a tendency that one-year survival rate in normal NSE value group was higher than that in high NSE value group（P=0.057）.[Conclusions ] Serum NSE may serve as a indicator for monitoring therapeutic effect and evaluating prognosis in NHL.
出处
《中国肿瘤》
CAS
2006年第1期50-53,共4页
China Cancer
基金
国家自然科学基金资助项目(30471976)
广东省自然科学基金资助项目(2004-139)
作者简介
通讯作者：吕跃
