摘要
目的:探讨人乳头瘤病毒与宫颈癌及癌前期病变的相关性。方法:选取2004年12月-2005年7月我院妇科宫颈病门诊妇女 1689例,取宫颈刷出物同时作宫颈薄层液基细胞学涂片与HPV-DNA检测,HPV-DNA检测方法是第二代杂交捕获法,可一次检测 13种高危型HPV病毒,分析HPV感染与宫颈癌及癌前期病变的关系。结果:HPV-DNA检出率随宫颈癌变程度加重呈趋势性升高,1689例病人中高危型HPV检出率为25．16％(425／1689),宫颈癌及癌前期病变中为90．35％(234／259)。结论:高危型HPV是诱发宫颈癌及癌前期病变的重要病因学因素。第二代杂交捕获法可作为官颈癌的一种筛查方法。
Objective： To investigate the relationship between human papillomavirus and cervical carcinoma and cervical intraepithelial neoplasia. Methods：From Decemder 2004 to July 2005,1689 outpatient women were screened high risk types of human papillomavirus（HPV） using Hybrid Capture Ⅱ and cervical cytology using the ThinPrep Pap Smear fluid-based system. The Hybrid Capture Ⅱ can detect 13 types of high-risk HPV DNA. Meanwhile,colposcopy and histological examination on cervical tissue were performed on all patients. Results： HPV infection rates increased according to the seriousness degree of cervical lesions. The infection rate of high-risk HPV DNA of all patient was 25. 16 % （425/1689）, the patient of cervical carcinoma and cervical intraepithelial neoplasia was 90. 35 % （234/259）. Conclusion： High-risk HPV is the major cause of cervical carcinoma and cervical intraepithelial neoplasia. So the Hybrid Capture Ⅱ could be used for screening primary cervical carcinoma.
出处
《中国临床医学》
北大核心
2005年第6期1061-1062,共2页
Chinese Journal of Clinical Medicine
关键词
人乳头瘤病毒
宫颈病变
杂交捕获
Human papillomavirus
Cervical lesion
Hybrid capture
