摘要
为了设计合成具有更高生物活性的化合物,以3-芳基-4-氨基-5-巯基-1,2,4-三唑与α-噻吩甲醛反应,通过微波法和传统方法设计合成了10个含1,2,4-三唑和噻吩环的希夫碱类化合物,其结构经IR1、H NMR、M S和元素分析确证。对两种方法的优缺点进行了比较。同时对6种病原菌进行了生物活性测试,结果发现,在50mg/L下,化合物IIe、IIf对6种病菌的抑制率大于62%。所有目标化合物对苹果轮纹病菌Dochiorella gregaria和水稻纹枯病菌Rhizatonia solani的抑制率均大于85%。
In order to synthesis some compounds with better fungicidal activity, the reaction of 3-aryl-4- amino-5-mercapto-1,2,4-S-triazoles with α-thiophaldehyde in the presence of absolute actonitrile were investigated and ten Schiff bases of triazole and thiophene were obtained by microwave method and traditional method in comparison. Their structures were comfirmed by elemental analysis, IR, ^1H NMR and MS. The results to six kinds of pathogenic species of the biological test showed that the compounds Ⅱe and Ⅱf had good inhibitory activities（inhibition rate≥62% ） and all of the compounds showed good inhibitory activities （ inhibition rate ≥ 85 % ） to Dothiorella gregaria and Rhizoctonia solani at 50 mg/L.
出处
《农药学学报》
CAS
CSCD
2005年第4期353-356,共4页
Chinese Journal of Pesticide Science
基金
湖北省科技攻关项目(2003AA3010B08)
关键词
希夫碱
三氮唑
噻吩
杀菌活性
Schiff base
triazole
thiophene
fungicidal activity
作者简介
张欣（1982-），女，江西人，硕士研究生；
通讯作者：覃章兰（1947-），女，湖北人，副教授，主要从事有机合成研究．联系电话：027-7863638；E-mall：qinzhanglan0@163．com
