摘要
目的:研究白川胶囊的镇痛镇静作用。方法:热板法测定小鼠痛阈,观察白川胶囊对小鼠痛阈的影响;醋酸致痛法,观察药物对小鼠扭体次数的影响;计数给药前后小鼠自主活动次数,研究该药对自主活动的影响。结果:白川胶囊0.6g.kg-1组的痛阈与常水组相比较P<0.05,镇痛率为58.3%;0.3,0.15g.kg-1组的痛阈有降低趋势,但无统计学意义;0.6,0.3g.kg-1两个剂量均可减少小鼠的扭体次数,镇痛率分别为67.9%和55.8%;组间比较及与给药前比较,大、中、小剂量均可显著减少小鼠自主活动次数(P<0.05)。结论:白川胶囊有明显的镇痛镇静作用。
OBJECTIVE To study the analgesia and sedation effects of Baichuan capsule. METHODS Mice＇ s pain thresholds were measured with hot plate method in order to observe the influences of Baichuan capsule on them and we observed the influences of this drug on mice＇ s torsional posture numbers with acetic acid causing pain. We also studied the influences of the drug on mice＇s spontaneous activities by comparing spontaneous activities before ig with that after doing so. RESULTS Comparing with saline group, the pain thresholds of 0.6 g·kg^-1 group of Baichuan capsule reduced markedly （P 〈0.05） and its analgesia percentage was 58.3%. In 0.3 and 0.15 g· kg^-1 groups , the pain thresholds had decreasing tendency ,but no statistics significance. 0.6 and 0.3 g·kg^-1 of this drug could decrease mice＇s torsional posture numbers and their analgesia percentage were 67.9% and 55.8% respectively. Various dosages of Baichuan capsule could decrease mice＇s spontaneous activities significantly （ P 〈 0.05 ） by comparing one group with another and before ig. CONCLUSION Baichuan capsule has significant analgesia and sedation effects.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2006年第1期20-22,共3页
Chinese Journal of Hospital Pharmacy
基金
陕西省自然科学基金资助项目(编号:2000SM41)
作者简介
赵万红，男，博士，讲师，电话：0719-8891142，8469198
