摘要
原发住肝癌易发生肝内转移，其术后复发率很高。为寻找有效的方法以降低术后的复发率，我们用抗ｐ５３和抗ＰＣＮＡ单克隆抗体对１０２例手术切除的肝癌标本作免疫组化检测。本文分析了肝癌的不同病理形态，ｐ５３，ＰＣＮＡ情况，结果表明：ＰＣＮＡ指数与ｐ５３的表达呈正相关系，ＰＣＮＡ指数与肿瘤大小，肿瘤包膜，组织分化程度无统计学差异；ｐ５３的表达多见于大肝癌中，但与肿瘤包膜，组织分化程度无统计学差异。ＰＣＮＡ和ｐ５３的免疫组化方法虽然简单，但实用，能为预后和临床治疗提供有用的指标，高指数ＰＣＮＡ或高表达ｐ５３的肝癌术后复发率高，预后差；这些病人术后应接受积极的辅助治疗，术后的介人治疗（栓塞化疗）能降低其术后复发率，提高生存率。
The intrahepatic recurrence rate of the patients after hepatectomy is very high.With theaim to decrease the recurrence rate of PIC patients after heLpatectomy,102 specimens obtained from PLCwere examined immunohistochemically using anti-p53 and anti-pCNA monoclonal antibodies.This paperanalyzed the different pathologic features,significance of labeling index of PCNA and expression of p53 inPLC and its values for clinical treatment.The results showed that the labeling index of PCNA had no statis-tical difference with tumor size,capsule formation,degree of histologic differentiation in PLC(P>0.05).The expression of p53 was more frequent in large tumor than that in small tumor(P<0.05),but had nostatistical relation to tumor capsule formation,degree of histologic differentiation(P>0.05)The labelingindex of PCNA and expression of p53 had positive correlation(P<0.01).Although the assessment of PCNAand p53 immunohistochemical staining are simple methods,but they could provide very useful informationfor the prognosis and treatment of PLC.The high labeling index of PCNA or over- expression of p53 re-sulted in high risk of tumor recurrence and poor survival.Adjuvant therapy should be given to these pa-tients.Such as transcathether hepatic arterial chemoenbolization after hepatectomy can decrease the recur-rence rates and improve the survival rate of PLC patients.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1996年第1期45-47,共3页
Chinese Journal of Cancer
基金
国家教委科研基金
