期刊文献+

基于玻璃基底微流控芯片的制备 被引量:4

The Fabrication of Microfluidic Channels on Soda-Lime Glass
在线阅读 下载PDF
导出
摘要 介绍一种基于玻璃基底微流控芯片的制作方法,通过光刻工艺在玻璃基底表面刻蚀出微通道。利用氧等离子体对聚二甲基硅氧烷(Polydimethylsiloxane,PDMS)和微通道所在的基底表面进行处理,使PDMS与基底表面性质由疏水性变为亲水性,完成PDMS与玻璃基底的共价键结合。通过实验表明,经氧等离子体处理之后的PDMS与玻璃基底的密封效果较好。鉴于PDMS具有良好的热稳定性,无毒性,以及较好的光学特性等,此微流控芯片可用于生物医学以及化学领域中的化学发光及荧光检测。 A fabrication procedure about microfluidic channels on soda - lime glass is described.The microchannels fabrication procedures is based on the semiconductor fabrication technology and etch the microfluidic channels using lithography. The PDMS and glass substrate can form the covalent bonding after oxygen plasma process. The SEM pictures and tests show the PDMS seals the microchannels well and tightly. Because of the optics and calorifics, this microfluidic chips can be used to detect the luminescence and fluorescence.
出处 《生物医学工程研究》 2005年第3期179-182,共4页 Journal Of Biomedical Engineering Research
关键词 微流控芯片 聚二甲基硅氧烷 氧等离子体 曝光 显影 湿法刻蚀 Microfluidic chips Polydimethylsiloxane(PDMS) Oxygen plasma Exposure Developer Wet etch
作者简介 程佳(1980-),男,东南大学硕士研究生。研究方向:生物传感器、MEMS器件。
  • 相关文献

参考文献12

  • 1[1]Bernhard H.Weigl,Bardell,Ron L.Catherine R.Cabrera.Lab - on - a -chip for drug development[J].Advanced drug delivery reviews,2003,55:349 - 377.
  • 2[2]Kutchoukov,V.G.Laugere,F.vanderVlist,W.et al.Fabrication of nanofluidic devices using glass - to - glass anodic bonding [J].Sensors and actuators,2004,A (114):521-527.
  • 3[3]Berthold,A.Nicola,L.Sarro,P.M.et al.Glass - to - glass anodic bonding with standard ic technology thin films as intermediate layers[J].Sensors and actuators,2000,A (82):224- 228.
  • 4[4]David C.Duffy,J.Cooper McDonald,Olivier J.A,et al.Rapid prototyping of microfluidic systems in poly (dimethylsiloxane) [J].Anal.Chem,1998,70:4974 - 4984.
  • 5[5]Carlo S.Effenhauser,Gerard J.M.Bruin,Aran Paulus,et al.Integrated capillary electrophoresis on flexible Silicone microdevices:analysis of DNA restriction fragments and detection of single DNA molecules on Microchips[J].Anal.Chem,1997,69:3451-3457.
  • 6[6]Andrew M Christensen,David A Chang- Yen,Bruce K Gale.Characterization of interconnects used in PDMS Microfluidic systems[J].Micromech.Microeng,2005,15:928-934.
  • 7[7]Kazuo Hosokawa,Kotaro Hanada,Ryutaro Macda.A Polydimethylsiloxane (PDMS) deformable diffraction grating for monitoring of local pressure in Microfluidic devices[J].Micromech.Microeng,2002,12:1-6.
  • 8叶美英,方群,殷学锋,方肇伦.聚二甲基硅氧烷基质微流控芯片封接技术的研究[J].高等学校化学学报,2002,23(12):2243-2246. 被引量:22
  • 9金鹏,谭久彬,刘岩.PDMS微小流路微加工技术的研究[J].微细加工技术,2001(3):31-34. 被引量:4
  • 10孟斐,陈恒武,方群,朱海霖,方肇伦.聚二甲基硅氧烷微流控芯片的紫外光照射表面处理研究[J].高等学校化学学报,2002,23(7):1264-1268. 被引量:26

二级参考文献16

  • 1杨玉昆 廖增琨.合成胶粘剂[M].北京:科学出版社,1983.449.
  • 2杨玉昆 等.合成胶粘剂[M].北京:科技出版社,1980..
  • 3McDonald J C, Duffy D C, Anderson J R, et al. Fabrication of Microfluidic System in Poly(dimethysiloxane)[J]. Electrophoresis,2000,21,27 - 40.
  • 4Terry S C, JermanJH, Angell J B. A Gas Clromatographic Air Analyzer Fabricated on a Silicon Wafer[J].IEEE Trans Elec Dev,1979,26:1880.
  • 5Harrison D J, Fluri K, Seiler K, et al. Micromachining a Miniaturized Capillary Electrophoresis Based Chemical Analysis System on a Chip[J]. Science, 1993,261,895 - 897.
  • 6Manz A, Miyahara Y, Miura J, et al. Design of an Open-tubular Column Liquid Chromatograph Using Silicon Ohip Techmology[J]. Sensor and Actuators, 1990,B1 :249 - 255.
  • 7Shoji S, Esashi M, Masuo T. Prototype Miniature Blood Gas Analyser Fabricated on a Silicon Wafer[J]. Sensor and Actuators, 1998,14:101 - 107.
  • 8Manz A, Simon W. Potentiometric Detector for Fast High-performance Open-tubular Column Liquid Chromatography [J] .Anal Chem,1987,59:74- 79.
  • 9Grasz B, Neyer A, Johnck M, et al.A new PMMA-microchip device for isotachophoresis with integratedconductivity detector ,Sensors and Actuators B,2000,72:249 -258.
  • 10Duffy D C, McDonald J C, Schueller O J A, et al. Rapid Prototyping of Microfluidic System in Poly(dimethylsiloxane) [ J ]. Anal Chem, 1998 , 70 , 4974 - 4984.

共引文献41

同被引文献28

引证文献4

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部