摘要
目的对恶性血管球瘤(MGT)的病理特征、诊断要点及其鉴别进行探讨。方法观察1例鼻窦MGF的病理形态学变化,经多种免疫组化标记、特染并结合文献复习进行讨论。结果鼻窦MGF患者,表现为反复鼻出血和鼻腔肿物。镜下以肿瘤细胞较小、轻度异型性、核分裂象易见、胞质透明、富于血窦状血管为特点;免疫组化瘤细胞CD34、EMA、P63及CK(34βE12)强(+);collagenⅥ,FⅧ弱(+):网状纤维染色见嗜银纤维分布在细胞之间。结论鼻窦恶性血管球瘤是罕见的软组织肿瘤,主要应与透明细胞癌、肌上皮肿瘤等鉴别;依靠病理形态、免疫组化及网状纤维染色相结合进行诊断。
Objective To explore the clinicopathological features and diagnosis of the malignant glomus tumor. Methods One case of malignant glomus tumor was described with pathological, immunohistochimical staning and review of the related literature. Results A tumor mass was found in the nasal cavity in a 49-year-old man with recurrent epistaxis. Microscopically the glomus tumor was composed of small cells with clear cytoplasm surrounded numerous, branching vessels. Immunohistochemically, the tumor cells were strongly positive for CD34, EMA, P63 and CK （34βE12） , and weakly positive for collagen Ⅳ , F Ⅷ, and negative for vimentin, actin, desmin, Myo, melenoma, S-100, NSE, GFAP, CgA and Syn. Reticular fiber stain revealed the characterstic arrangement of tumour cells. Conclusions Malignant glomus tumor of the niasal cavity is an extremely rare neoplasm, and can be misdiagnosed as clear cell carcinoma, myoepithelial tumor or other tumors. The diagnosis of this tumor depends mostly on cytomorphology, immunohistochemical and reticular fibre staining.
出处
《诊断病理学杂志》
CSCD
2005年第6期432-434,i0015,共4页
Chinese Journal of Diagnostic Pathology
关键词
血管球瘤
恶性
病理学
鉴别诊断
免疫组化
Glomus tumor, malignant
Pathology
Diffrential diagnosis
Immunohistochemistry
