摘要
目的观察盐敏感者胰岛素抗性与应激血压反应的关系。方法对３３例高血压病患者和２７例血压正常对照者用静脉盐水负荷和速尿缩容相结合的方法确定盐敏感性（ＳＳ）基础上，进行糖耐量、胰岛素释放试验；精神激发，冷加压和运动等试验。结果ＳＳ与盐不敏感者（ＳＲ）比较，空腹及糖负荷后各时点血糖及胰岛素含量均明显增高，胰岛素敏感指数降低（Ｐ均＜０．０５）；空腹血胰岛素在百分位Ｐ７５以上者或胰岛素敏感指数在百分位Ｐ２５以下者，精神激发及冷加压后平均动脉压上升幅度（ΔＭＡＰ）明显增加，且与空腹血胰岛素水平呈正相关（ｒ值分别为０．３８１及０．４２３，Ｐ＜０．０５），与胰岛素敏感指数呈负相关（ｒ值为－０．３９３和－０．２６７，Ｐ＜０．０５）。结论盐敏感者有胰岛素抗性增加的表现。
Aim\ To observe the relationships between the insulin resistance and the blood pressure responses to stresses in hypertensive subjects with salt sensitivity.\ Methods\ The intravenous saline load and the furosemide sodium volume depletion tests were undertaken to determine salt sensitivity(SS) in 33 cases with essential hypertension and 27 normotensives. Oral glucose tolerance test and insulin release test were determined, and mental arithmetical stress, cold pressor test and exercise test were perfermed.\ Results\ The plasma glucose and insulin concentration in every time point after glucose load were higher in SS than in salt resistant(SR) ( P <0 05 or 0 01); the insulin sensitive index was lower in SS than in SR; the mean blood pressure increased amplitude(ΔMAP) during mental arithmatical stress and cold pressor test was significantly increased in subjects whose fasting insulin content was greater than P 75 (the 75th percentile) and whose insulin sensitive index was lower than P 25 (the 25th percentile). ΔMAP was positively correlated with fasting plasma insulin content ( r=0 381,P<0 05;r=0 423,P <0 01) and was negtively correlated with insulin sensitive index( r=-0 393,P<0 01; r=-0 267, P <0 05).\ Conclusion\ There were significantly increaed blood pressure responses to stress associated with increased insulin resistance in subjects with salt sensitivity.
出处
《高血压杂志》
CSCD
1996年第3期194-196,共3页
Chinese Journal of Hypertension
关键词
盐敏感性
血压
胰岛素
抗性
应激
salt sensitivity\ blood pressure\ stress\ insulin resistance
