摘要
４０只大鼠随机分为４组，３０只采用气管内注入感染法建立肺炎克雷白杆菌性肺炎模型，按成人常用临床治疗剂量折算出大鼠的等效剂量，连续７ｄ腹腔注射头孢三嗪（ＣＲＯ）和丁胺卡那霉素（ＡＭＫ），活体取材测定免疫指标。结果显示：（１）各组对胸腺、脾重量及脾生发中心Ｂ细胞密度无影响；（２）ＣＲＯ能增强中性粒细胞化学发光；（３）ＣＲＯ增强巨噬细胞酸性磷酸酶活性，ＡＭＫ抑制巨噬细胞吞噬功能和抗体依赖性细胞介导的细胞毒作用；（４）ＡＭＫ使Ｔ淋巴细胞ＣＤ和ＣＤ亚群降低。结果提示ＣＲＯ和ＡＭＫ能分别促进和抑制肺炎大鼠的免疫应答反应。
Forty Wistar rats were randomly divided into 4 groups.Thirty rats were infected with pneumoniaeKlebiella species by the intratracheal peroral routs,Ceftriaxone(CRO)and amikacin(AMK)were adiminis-tered at therapeutic doses intraperitoneally for 7 days and several immunologic parameters were measured.The results showed: (1)The weight of organs(thymus and spleen) and B cell density in the germinal centreof splenic follicles had no significant alteration in each groups;(2)CRO enhanced the chemoluminescenceplateau of polymorphonuclear leukocytes;(3)CRO increased the ACP activity,AMK decreased the phagocyto-sis and ADCC;(4)AMK decreased the number of CD and CD Tcells The resuIts indicated that CRO andAMK could advance or restrain the immune response in pneumonic rats,respectively.
出处
《军医进修学院学报》
CAS
1996年第2期135-138,共4页
Academic Journal of Pla Postgraduate Medical School
