摘要
为探讨联合用药治疗矽肺的效果，比较了克矽平和汉防己甲素、柠檬酸铝和磷酸羟基喹哌、汉防己甲素和磷酸羟基喹哌联合用药与相应药物单一用药治疗大鼠实验性矽肺的效果。采用多指标加权疗效比值（ＷＥＲ）的综合评价方法表明，无论是预防性用药或病后治疗，联合用药组动物的治疗效果均优于相应药物单一用药的结果。停药后病变有所进展，但重新给药后矽肺病变仍可得到控制，亦以联合用药组的效果为好。当给药剂量减为半剂量联合用药时仍可得到相同的结果，显示了药疗效的相加作用。以上结果为矽肺病人的联合用药治疗方案提供了科学依据。
hetherapeuticeficacyofthreevarietiesofcombineduseofanti-silicosisdrugsonratex-perimentalsilicosiswasstudied.Thethreevarietieswere:polyvinylpyridine-N-oxide(PVNO)andte-tran-drine(TD),aluminiumcitrate(ALC)andquinolylpiperazinehydroxylphosphate(QOHP),andTDandQOHP.Comprehensiveevaluationofmulti-indiceswithweighteficacyratio(WER)wasused.Theresultsshowedthattherapeuticeficacyofcombinedtreatmentsweremoreeficientthanthesingletreatmentwithrelevantdrugs.Thesilicoticlesionsprogressedwhenthedrugswerewithdrawn,butcouldbecon-troledafterreadministrationofdrugs,andinthiscasetheeficacyofcombined-treatmentgroupswereal-sobeter.Itisconcludedthattheresultsofthisstudywouldprovidescientificbasisforclinicalycom-bineduseofanti-silicosisdrugsmentionedabove.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
1996年第5期281-283,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词
矽肺
治疗
联合用药
综合评价
SilicosistreatmentCombineduseofanti-silicoticdrugsComprehensiveevaluation
