摘要
目的:探讨系统性红斑狼疮(SLE)患者血中白细胞介素18(IL-18)的变化及临床意义。方法:采用双抗体夹心(ELISA)法对SLE患者及正常对照者血中IL-18进行测定。结果:活动期SLE血中IL-18明显增高,SLE伴尿常规明显异常者IL-18增高最明显,IL-18水平与尿蛋白的增加呈正相关,与SLE活动指标中抗ds-DNA呈正相关,与C3、C4变化呈负相关。结论:IL-18通过直接或间接影响某些免疫过程参与SLE的病理损伤过程。
Objective： To study the change and clinical significance of interleukin-18 （IL-18） in patients with systemic lupus erythematosus （SLE）. Methods： The level of IL-18 was measured in SLE patients and normal subjects by enzyme-linked immunosorbent assay. Results. The level of IL-18 in patients with active SLE was much higher than that in normal subjects. The level of IL-18 increased most obviously and was positively related to the increase of the urine protein in SLE patients with abnormal urine routine. IL-18 was positively related to anti-ds-DNA antibody but negatively related to C3 and C4. Conclusion： IL-18 participates directly or indirectly in the pathological damage of SLE by affecting immune processes.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2005年第6期577-578,共2页
Journal of China Medical University
